LEVELS OF ARACHIDONIC-ACID AND ITS METABOLITES IN THE SKIN IN HUMAN ALLERGIC AND IRRITANT CONTACT-DERMATITIS
LEVELS OF ARACHIDONIC-ACID AND ITS METABOLITES IN THE SKIN IN HUMAN ALLERGIC AND IRRITANT CONTACT-DERMATITIS
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DOI：
10.1111/j.1365-2133.1984.tb04012.x
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发表时间：
1984-01-01
影响因子：
10.3
通讯作者：
MISCH, K
中科院分区：
文献类型：
--
作者：
BARR, RM;BRAIN, S;MISCH, K
在由镍和铬酸盐过敏原引起的人类接触性皮炎的皮肤中发现花生四烯酸和前列腺素E2浓度增加，但未发现12-羟基-二十碳四烯酸。显着水平的中性粒细胞的趋化活性，具有类似的性质，白三烯B4，被发现在一个高比例的渗出液从发炎的皮肤过敏原治疗，但不从未经处理的皮肤渗出液。在苯扎氯铵引起的原发性刺激性皮炎中，花生四烯酸及其代谢产物均未增加。
Increased concentrations of arachidonic acid and prostaglandin E2, but not 12-hydroxy-eicosatetraenoic acid, were found in the skin in human contact dermatitis due to Ni and chromate allergens. Significant levels of neutrophil chemokinetic activity, with similar properties to leukotriene B4, were found in a high proportion of exudates from inflamed skin treated with allergen but not in exudates from untreated skin. Neither arachidonic acid nor its metabolites were increased in primary irritant dermatitis due to benzylalkonium chloride.