Ethanol consumption by C57BL/6 mice: Influence of gender and procedural variables
Ethanol consumption by C57BL/6 mice: Influence of gender and procedural variables
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DOI：
10.1016/s0741-8329(98)00055-x
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发表时间：
1999-04-01
期刊：
影响因子：
2.3
通讯作者：
McGroarty, KK
中科院分区：
文献类型：
--
作者：
Middaugh, LD;Kelley, BM;McGroarty, KK
C57BL/6 （C57）小鼠无论在连续或有限的情况下，在不剥夺食物或水的情况下，雌雄均消耗大量乙醇。食物剥夺增加了乙醇的消耗量，消耗量取决于动物在什么时候进行测试，参照他们的日常食物分配。如果小鼠在餐后进行高口渴动机测试，而不是餐前进行测试，则乙醇消耗量更大（类似于10 g/kg/30 min相比，类似于4.5 g/kg/30 min）。然而，当小鼠处于低口渴动机时（即餐前测试或测试期间有水），对乙醇的偏好比水更大。与雄性相比，雌性小鼠在连续接触或仅限于昼夜周期黑暗（活跃）阶段的第一个小时时消耗更多的高乙醇浓度溶液（10%）。此外，与雄性相比，雌性小鼠在饮酒经历的几天里表现出增加的乙醇消耗量。最后，尽管本实验中食物剥夺条件下的乙醇消耗量没有性别差异，但雌性C57小鼠的血液乙醇浓度高于雄性C57小鼠，这一发现在啮齿类动物中没有报道，但在人类中很常见。(C) 1999 Elsevier Science Inc.；版权所有。
Both sexes of C57BL/6 (C57) mice consumed substantial quantities of ethanol without food or water deprivation whether access was continuous or limited. Food deprivation increased the amount of ethanol consumed, and the amount consumed depended upon when the animals were tested with reference to their daily food allotment. Ethanol consumption was greater if the mice were tested postprandially, high thirst motivation, rather than preprandially (similar to 10 vs. similar to 4.5 g/kg/30 min). Preference for ethanol over water, however, was greater when mice were under low thirst motivation (i.e., tested preprandially or with water available during the test). Compared to males, female mice consumed more of a high-ethanol concentration solution (10%) when access was continuous or limited to the first hour of the dark (active) phase of the circadian cycle. Also, in contrast to males, female mice exhibited increased ethanol consumption across days of drinking experience. Finally, although ethanol consumption under the food deprivation conditions of this experiment did not differ according to sex, females had higher blood ethanol concentrations than male C57 mice, a finding not previously reported for rodents but common to humans. (C) 1999 Elsevier Science Inc. All rights reserved.