Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication.
Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication.
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DOI：
10.4161/bact.23830
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发表时间：
2012-10-01
期刊：
影响因子：
--
通讯作者：
Salmond GP
中科院分区：
文献类型：
--
作者：
Blower TR;Short FL;Fineran PC;Salmond GP
细菌和噬菌体之间的全球相互作用产生了许多在生物技术中有用的大分子，通过细菌防御和病毒反击措施的共同进化跷跷板。细菌可以利用失败的感染系统来保护自己，这种系统在受感染的细胞中诱导利他性自杀，从而以受感染个体为代价来保护克隆种群。我们最近的论文描述了噬菌体ΦTE如何成功地颠覆了质粒传播的流产感染系统的活性。ΦTE进化出小RNA抗毒素的模拟物，其天然抑制这种抗病毒机制的活性毒素组分。这些突变体通过转导编码败育感染系统的质粒进一步操纵宿主群体的行为。因此，转导子被失败的感染系统所奴役，响应于原始噬菌体群体的感染而自杀。实际上，新的宿主被一种“上瘾的利他主义”感染，这对抗药性噬菌体有利。
The global interplay between bacteria and bacteriophages has generated many macromolecules useful in biotechnology, through the co-evolutionary see-saw of bacterial defense and viral counter-attack measures. Bacteria can protect themselves using abortive infection systems, which induce altruistic suicide in an infected cell and therefore protect the clonal population at the expense of the infected individual. Our recent paper describes how bacteriophage ΦTE successfully subverted the activity of a plasmid-borne abortive infection system. ΦTE evolved mimics of the small RNA antitoxin that naturally inhibits the active toxin component of this anti-viral mechanism. These mutant phages further manipulated the behavior of the host population, through transduction of the plasmid encoding the abortive infection system. Transductants thereby became enslaved by the abortive infection system, committing suicide in response to infection by the original phage population. In effect, the new host was infected by an “addictive altruism,” to the advantage of the resistant bacteriophage.