Immune responses in the bicolor damselfish, Pomacentrus partitus, and their potential role in the development of neurogenic tumours
Immune responses in the bicolor damselfish, Pomacentrus partitus, and their potential role in the development of neurogenic tumours
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双色雀鲷 Pomacentrus partitus 的免疫反应及其在神经源性肿瘤发展中的潜在作用
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
E. Mckinney
中科院分区：
文献类型：
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作者：
M. Schmale;E. Mckinney
佛罗里达州南部珊瑚礁上的双色丹自鱼通常受到一种由雪旺细胞瘤组成的疾病的影响。这种疾病的几个特征被称为丹自鱼神经纤维瘤病(DNF)，表明这些鱼的免疫系统可能在肿瘤的表达和进展速度中发挥重要作用。大多数处于DNF晚期的FISH在脾和肾中都表现出异常的、可能是退行性的组织学变化，这表明可能正在发生一种普遍的、非特异性的免疫反应抑制。这一假设得到了有丝分裂原诱导的增殖和混合白细胞反应的结果的支持，这些结果表明，涉及前肾和脾的免疫系统的几种功能几乎完全失效。肿瘤内可见少量粒细胞和单核/巨噬细胞。
Bicolor damselfish on southern Florida reefs are commonly affected by a disease consisting of Schwann cell tumours. Several features of this disease, termed damselfish neurofibromatosis (DNF), indicate that the immune system of these fish may play an important role in the expression and rate of progression of the tumours. The majority of fish in the advanced stages of DNF showed abnormal, presumably degenerative, histological changes in both the spleen and kidney, suggesting that a general, non-specific suppression of immune responses might be occurring. This hypothesis was supported by results of mitogen-induced proliferation and mixed leucocyte responses in fish with DNF which indicated a near total failure of several functions of the immune system involving the pronephros and the spleen. A sparse infiltrate of granulocytes and monocyte/macrophages was seen in these tumours.