Survivin as a Prognostic Marker for Urothelial Carcinoma of the Bladder: A Multicenter External Validation Study
Survivin as a Prognostic Marker for Urothelial Carcinoma of the Bladder: A Multicenter External Validation Study
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DOI：
10.1158/1078-0432.ccr-08-2554
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发表时间：
2009-11-15
影响因子：
11.5
通讯作者：
Lotan, Yair
中科院分区：
文献类型：
--
作者：
Shariat, Shahrokh F.;Karakiewicz, Pierre I.;Lotan, Yair
目的：本研究的目的是外部验证生存素作为膀胱癌的预后指标在一个大的多机构队列根治性cyclosthetic.Methods：该研究包括726例根治性cyclostheticandbilateral盆腔淋巴结切除术治疗的患者的价值。Survivin染色和评分用自动化系统结合先进的颜色检测软件进行。表现出至少10%反应性的标本被认为是改变的。结果：在控制标准临床病理特征影响的多变量分析中，Survivin是疾病复发和癌症特异性生存的独立预测因子（风险比，类似于1.6; P值
Purpose: The aim of the current study was to externally validate the value of survivin as a prognostic marker for bladder cancer in a large multi-institutional cohort of patients treated with radical cystectomy.Methods: The study comprised 726 patients treated with radical cystectomy and bilateral pelvic lymphadenectomy. Survivin staining and scoring were done with automated systems coupled with advanced color detection software. Specimens showing at least 10% reactivity were considered altered. Predictive accuracy was quantified using the concordance index and 200-bootstrap resamples were used to reduce overfit bias.Results: Survivin was an independent predictor of disease recurrence and cancer-specific survival in multivariable analyses that controlled for the effects of standard clinicopathologic features (hazard ratios, similar to 1.6; P values