Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study
Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study
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DOI：
10.1093/jnci/djr151
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发表时间：
2011-06-01
影响因子：
10.3
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
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作者：
Wilson, Kathryn M.;Kasperzyk, Julie L.;Mucci, Lorelei A.
咖啡含有许多生物活性化合物，包括咖啡因和酚酸，它们具有强大的抗氧化活性，可以影响葡萄糖代谢和性激素水平。由于这些生物活动，咖啡可能与前列腺癌的风险降低。方法我们进行了前瞻性分析的47 911名男子在卫生专业人员的后续研究谁报告摄入量的定期和脱咖啡因的咖啡在1986年和此后每4年。从1986年到2006年，共确定了5035例前列腺癌患者，其中包括642例致命性前列腺癌患者，定义为致命性或转移性。我们使用考克斯比例风险模型来评估咖啡和前列腺癌之间的关系，并对吸烟、肥胖和其他变量的潜在混杂因素进行了调整。所有P值均来自双侧检验。结果1986年的平均咖啡摄入量为每天1.9杯。与不饮酒者相比，每天饮用六杯或更多杯的男性患前列腺癌的校正相对风险较低（RR = 0.82，95%置信区间[CI] = 0.68至0.98，P趋势= 0.10）。对于致命的前列腺癌，这种关联更强（每天喝六杯以上咖啡的消费者：RR = 0.40，95% CI = 0.22至0.75，P趋势= 0.03）。咖啡消费与非晚期或低度癌症的风险无关，与高度癌症的风险呈弱负相关。普通咖啡和无咖啡因咖啡与致死性癌症的负相关性相似（每天增加一杯：普通咖啡的RR = 0.94，95% CI = 0.88至1.01，P = 0.08;无咖啡因咖啡的RR = 0.91，95% CI = 0.83至1.00，P = 0.05）。年龄调整后的发病率最高的男性（=每天6杯）和最低（不喝咖啡）每10万人年中，咖啡摄入量分别为425和519例前列腺癌，分别为34和79例致命前列腺癌，结论：我们观察到咖啡摄入量与致命性前列腺癌风险之间存在强烈的负相关。这种关联似乎与咖啡中的非咖啡因成分有关。
Background Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels. Because of these biological activities, coffee may be associated with a reduced risk of prostate cancer.Methods We conducted a prospective analysis of 47 911 men in the Health Professionals Follow-up Study who reported intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter. From 1986 to 2006, 5035 patients with prostate cancer were identified, including 642 patients with lethal prostate cancers, defined as fatal or metastatic. We used Cox proportional hazards models to assess the association between coffee and prostate cancer, adjusting for potential confounding by smoking, obesity, and other variables. All P values were from two-sided tests.Results The average intake of coffee in 1986 was 1.9 cups per day. Men who consumed six or more cups per day had a lower adjusted relative risk for overall prostate cancer compared with nondrinkers (RR = 0.82, 95% confidence interval [CI] = 0.68 to 0.98, P-trend = .10 ). The association was stronger for lethal prostate cancer (consumers of more than six cups of coffee per day: RR = 0.40, 95% CI = 0.22 to 0.75, P-trend = .03). Coffee consumption was not associated with the risk of nonadvanced or low-grade cancers and was only weakly inversely associated with high-grade cancer. The inverse association with lethal cancer was similar for regular and decaffeinated coffee (each one cup per day increment: RR = 0.94, 95% CI = 0.88 to 1.01, P = .08 for regular coffee and RR = 0.91, 95% CI = 0.83 to 1.00, P = .05 for decaffeinated coffee). The age-adjusted incidence rates for men who had the highest (= 6 cups per day) and lowest (no coffee) coffee consumption were 425 and 519 total prostate cancers, respectively, per 100 000 person-years and 34 and 79 lethal prostate cancers, respectively, per 100 000 person-years.Conclusions We observed a strong inverse association between coffee consumption and risk of lethal prostate cancer. The association appears to be related to non-caffeine components of coffee.