Chemical heterogeneity of the living human brain: A proton MR spectroscopy study on the effects of sex, age, and brain region
Chemical heterogeneity of the living human brain: A proton MR spectroscopy study on the effects of sex, age, and brain region
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DOI：
10.1006/nimg.2000.0557
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发表时间：
2000-05-01
期刊：
影响因子：
5.7
通讯作者：
Apkarian, AV
中科院分区：
文献类型：
--
作者：
Grachev, ID;Apkarian, AV
在19-31岁年龄组的19名男性和女性正常志愿者之间比较了脑化学，使用体内质子磁共振波谱法在6个脑区和9种代谢物中进行。在8 cm（3）脑体素内，测量N-乙酰天冬氨酸、胆碱、谷氨酸、谷氨酰胺、GABA、肌醇、葡萄糖和乳酸相对于肌酸的相对浓度。这些测量在6个脑区进行：丘脑和扣带回，丘脑，感觉运动，背外侧前额叶和左半球的眶额叶皮质。总代谢物浓度在前额叶区最高（眶额叶皮质比丘脑和丘脑高28%，背外侧前额叶皮质高18.7%，P < 10（-7））。与19-20岁的受试者相比，25-31岁的受试者的眶额皮质（35%，P < 10（-7））和感觉运动皮质（16.7%，P < 10（-5））中的总代谢物浓度显著增加。这两个大脑区域也表现出性别依赖性，女性的代谢物浓度比男性高（感觉运动皮层增加9%，P < 0.002，眶额叶皮层增加2.1%）。大多数其他大脑区域没有显示出性别或年龄依赖性差异。结果表明，活的人脑是化学异质性的。化学异质性是性别和年龄依赖性和特定的大脑区域。(C)北京大学出版社.
Brain chemistry was compared between 19 male and female normal volunteers in the age group 19-31 years, across six brain regions and nine metabolites using in vivo proton magnetic resonance spectroscopy. The relative concentrations of N-acetyl aspartate, choline, glutamate, glutamine, GABA, inositol, glucose, and lactate were measured relative to creatine within 8 cm(3) brain voxels. These measurements were performed in six brain regions: thalamus and cingulate, insula, sensorimotor, dorsolateral prefrontal, and orbital frontal cortices in the left hemisphere, Total metabolite concentration was highest in prefrontal regions (28% higher in orbital frontal cortex and 18.7% higher in dorsolateral prefrontal cortex compared with insula and thalamus, P < 10(-7)). Subjects 25-31 years of age demonstrated a significant increase in total metabolite concentration in the orbital frontal cortex (35%, P < 10(-7)) and sensorimotor cortex (16.7%, P < 10(-5)) compared to those 19-20 years of age. These two brain regions also showed gender dependence, with women demonstrating increased metabolite concentrations compared to men (9% increase in sensorimotor cortex, P < 0.002, and 2.1% in orbital frontal cortex). Most other brain regions showed no gender- or age-dependent differences. The results indicate that the living human brain is chemically heterogeneous. The chemical heterogeneity is sex and age dependent and specific for brain region. (C) 2000 Academic Press.