Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
复制标题
DOI：
10.1126/science.aat7693
复制
发表时间：
2019-08-30
期刊：
影响因子：
56.9
通讯作者：
Wilson, C. H.
中科院分区：
文献类型：
--
作者：
Ganna, Andrea;Verweij, Karin J. H.;Wilson, C. H.
双胞胎和家庭研究表明，同性性行为在一定程度上受到基因的影响，但之前对相关特定基因的搜索一直力度不足。我们对477,522个个体进行了全基因组关联研究，发现了5个与同性性行为显著相关的基因座。总体而言，所有测试的基因变异占同性性行为变异的8%至25%，仅在男性和女性之间部分重叠，无法对个人的性行为进行有意义的预测。将这些结果与非异性恋者中同性占性伴侣总数比例的结果进行比较，表明从异性到同性性行为并不存在单一的连续体。总体而言，我们的发现提供了对同性性行为背后的遗传学的洞察，并突显了性行为的复杂性。
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.