Neural circuit flexibility in a small sensorimotor system.

Neural circuit flexibility in a small sensorimotor system.
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DOI:
10.1016/j.conb.2011.05.019
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发表时间:
2011-08
影响因子:
5.7
通讯作者:
Nusbaum MP
Nusbaum MP
中科院分区:
医学2区
文献类型:
--
作者:
Blitz DM;Nusbaum MP

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节律行为背后的神经元回路(中央模式发生器:CPG)可以在没有感觉输入的情况下产生节律运动输出。然而,感觉输入是产生行为相关的CPG输出的关键。在这里,我们讨论了最近的工作在十足类甲壳动物的口胃神经系统(STNS)识别细胞和突触机制,感觉输入选择特定的运动输出从CPG电路。这包括感觉神经元调节下行投射神经元对CPG回路的影响的几个例子。这种水平的分析在STNS中是可能的,这是由于对识别的回路、投射和感觉神经元的相对独特的访问。这些研究还揭示了感觉运动整合的额外自由度,这是节奏运动系统固有的广泛灵活性的基础。
Neuronal circuits underlying rhythmic behaviors (central pattern generators: CPGs) can generate rhythmic motor output without sensory input. However, sensory input is pivotal for generating behaviorally relevant CPG output. Here we discuss recent work in the decapod crustacean stomatogastric nervous system (STNS) identifying cellular and synaptic mechanisms whereby sensory inputs select particular motor outputs from CPG circuits. This includes several examples in which sensory neurons regulate the impact of descending projection neurons on CPG circuits. This level of analysis is possible in the STNS due to the relatively unique access to identified circuit, projection, and sensory neurons. These studies are also revealing additional degrees of freedom in sensorimotor integration that underlie the extensive flexibility intrinsic to rhythmic motor systems.
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发表时间: 2009-04-22
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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