Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease
Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease
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DOI：
10.1016/j.atherosclerosis.2005.05.008
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发表时间：
2006-02-01
期刊：
影响因子：
5.3
通讯作者：
Zou, Y
中科院分区：
文献类型：
--
作者：
Wang, B;Pan, J;Zou, Y
氧化应激可能在动脉粥样硬化的发展中发挥作用。本研究的目的是探讨 8-异前列腺素 F-2 α (8-iso-PGF(2 α)) 水平与冠状动脉疾病 (CAD) 之间的关系，并阐明 8-isoPGF(2 α) 是否可以独立添加到 CAD 程度的测量中。研究组由 241 名因疑似 CAD 而接受冠状动脉造影的连续患者组成。记录所有参与者的 8-iso-PGF(2α) 水平。分析显示，患有和不患有高血压的患者（P < 0.001）、糖尿病患者相对于非糖尿病患者（P < 0.05）以及男性相对于女性（P < 0.001）的 8-iso-PGF(2α) 水平存在显着差异。年龄和 8-iso-PGF(2α) 水平之间存在显着的正相关性 (P < 0.001)。 8-iso-PGF(2α) 水平与心血管危险因素的数量相关 (P < 0.001)。 CAD(+) 组的 8-iso-PGF(2α) 水平高于 CAD(-) 组（37.7 +/- 80.2 和 263.8 +/- 74.2 pg/ml，P < 0.001）。根据受影响血管的数量，8-iso-PGF(2α) 水平逐步升高（P < 0.001）。 8-iso-PGF(2α)水平与>50和>25%狭窄节段数(P<0.001)及冠状动脉狭窄程度评分呈显着正相关(P<0.001)。多变量逻辑回归分析表明为8-iso-PGF2。作为与 CAD 相关的独立因素（比值比，2.47，P=0.001）。结果表明，8-iso-PGF(2α)与接受冠状动脉造影的患者发生冠心病有关，也与中国人群的冠状动脉狭窄程度有关。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Oxidative stress may play a role in the development of atherosclerosis. The purpose of the present study was to explore the relationship between 8-isoprostaglandin F-2 alpha (8-iso-PGF(2 alpha)) levels and the presence of coronary artery disease (CAD) and to also clarify whether 8-isoPGF(2 alpha) might add independently to measures of CAD extent. The study group consisted of 241 consecutive patients who were undergoing coronary angiography for suspected CAD. 8-iso-PGF(2 alpha) levels were recorded for all participants. The analysis revealed a significant difference in 8-iso-PGF(2 alpha) levels in patients with and without hypertension (P < 0.001), in patients with diabetes relative to nondiabetic patients (P < 0.05), and in males respect to females (P < 0.001). A significant positive correlation was found between age and 8-iso-PGF(2 alpha) levels (P < 0.001). 8-iso-PGF(2 alpha) levels correlated with the number of cardiovascular risk factors (P < 0.001). 8-iso-PGF(2 alpha) levels were higher in the CAD(+) respect to the CAD(-) groups (37.7 +/- 80.2 and 263.8 +/- 74.2 pg/ml and P < 0.001). A stepwise elevation in the 8-iso-PGF(2 alpha) levels was found depending on the number of affected vessels (P < 0.001). The 8-iso-PGF(2 alpha) levels showed a significant positive correlation with the numbers of > 50 and > 25% stenotic segments (P < 0.001) and the extent score of coronary stenosis (P < 0.001). The multivariate logistic regression analysis indicated 8-iso-PGF2. as an independent factor associated with CAD (odds ratio, 2.47 and P=0.001). The results suggested that 8-iso-PGF(2 alpha) is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population. (c) 2005 Elsevier Ireland Ltd. All rights reserved.