Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis
Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2′-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis
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DOI：
10.1016/s0304-3835(97)00390-x
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发表时间：
1998-01-09
期刊：
影响因子：
9.7
通讯作者：
Shirai, T
中科院分区：
文献类型：
--
作者：
Cui, L;Mori, T;Shirai, T
为了确定间歇性激素操作对大鼠前列腺癌发生的促进阶段的影响，在用前列腺致癌物3，2 '-二甲基-4-氨基联苯治疗20周后，对F344大鼠给予睾酮和/或雌激素40周。为此，将丙酸睾酮（TP）和己烯雌酚（DES）分别引入2 cm和0.5 cm长的硅橡胶管中，并植入皮下组织中，重复7个周期，治疗30天，停药10天。间歇性给予TP可抑制前列腺腺癌的发展，并使侧前列腺和精囊浸润性癌的发生率略有增加，但不显着。DES的间歇给药完全抑制了所有部位的肿瘤发生，TP和DES的组合通常抑制前列腺肿瘤的发展。因此，在目前的实验条件下，没有强烈的增强作用的周期性激素操纵观察到大鼠前列腺癌的发生。事实上，情况似乎正好相反。(C)1998爱思唯尔科学爱尔兰有限公司
In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate a carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone propionate (TP) and diethylstilbestrol (DES) were introduced into silastic tubes, 2- and 0.5-cm long, respectively, and implanted into the subcutis for seven repeated cycles of 30 days treatment and 10 days withdrawal. Intermittent administration of TP resulted in suppression of veneral prostate adenocarcinoma development and slight but non-significant increases in the incidences of invasive carcinomas of the lateral prostate and seminal vesicles. Intermittent administration of DES completely suppressed tumorigenesis in all sites and the combination of TP and DES generally inhibited prostate tumor development. Thus, under the present experimental conditions, no strong enhancing effects of cyclic hormonal manipulation were observed on rat prostate carcinogenesis. Indeed, the opposite appeared to be the case. (C) 1998 Elsevier Science Ireland Ltd.