Cerebral cortical folding analysis with multivariate modeling and testing: Studies on gender differences and neonatal development
Cerebral cortical folding analysis with multivariate modeling and testing: Studies on gender differences and neonatal development
复制标题
DOI：
10.1016/j.neuroimage.2010.06.072
复制
发表时间：
2010-11-01
期刊：
影响因子：
5.7
通讯作者：
Gee, James C.
中科院分区：
文献类型：
--
作者：
Awate, Suyash P.;Yushkevich, Paul A.;Gee, James C.
本文提出了一种新的统计框架，人类皮质折叠模式分析，依赖于丰富的多元描述符的折叠模式在感兴趣的区域（ROI）。基于ROI的方法避免了基于空间归一化的方法所面临的问题，这些问题源于典型人类大脑皮层之间同源特征的缺乏。与通过单个数字总结折叠的典型基于ROI的方法不同，所提出的描述符统一了高维空间中表面几何形状的多个特征。（数百/数千维）这样，所提出的框架结合了ROI的可靠性-的分析与丰富的新的皮层折叠模式描述符本文提出了新的数学见解的关系，皮层复杂性与内，颅骨体积（ICV）它表明传统的复杂度描述符以不同的方式隐含地处理ICV差异，本文提出了一种新的应用非参数置换为基础的方法，严格的统计假设检验与多元皮质描述符，本文提出了两个交叉，应用所提出的框架研究性别之间和新生儿复杂先天性心脏病患者的折叠差异的截面研究两项研究都导致了新的有趣结果（C）2010 Elsevier Inc保留所有权利。
This paper presents a novel statistical framework for human cortical folding pattern analysis that relies on a rich multivariate descriptor of folding patterns in a region of interest (ROI). The ROI-based approach avoids problems faced by spatial normalization-based approaches stemming from the deficiency of homologous features between typical human cerebral cortices Unlike typical ROI-based methods that summarize folding by a single number, the proposed descriptor unifies multiple characteristics of surface geometry in a high-dimensional space (hundreds/thousands of dimensions) In this way, the proposed framework couples the reliability of ROI-based analysis with the richness of the novel cortical folding pattern descriptor This paper presents new mathematical insights into the relationship of cortical complexity with intra-cranial volume (ICV) It shows that conventional complexity descriptors implicitly handle ICV differences in different ways, thereby lending different meanings to "complexity" The paper proposes a new application of a nonparametric permutation-based approach for rigorous statistical hypothesis testing with multivariate cortical descriptors The paper presents two cross-sectional studies applying the proposed framework to study folding differences between genders and in neonates with complex congenital heart disease Both studies lead to novel interesting results (C) 2010 Elsevier Inc All rights reserved.