VERY HIGH-FREQUENCY OF REVERSION TO GUANIDINE RESISTANCE IN CLONAL POOLS OF GUANIDINE-DEPENDENT TYPE-1 POLIOVIRUS
VERY HIGH-FREQUENCY OF REVERSION TO GUANIDINE RESISTANCE IN CLONAL POOLS OF GUANIDINE-DEPENDENT TYPE-1 POLIOVIRUS
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DOI：
10.1128/jvi.64.2.664-671.1990
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发表时间：
1990-02-01
影响因子：
5.4
通讯作者：
HOLLAND, JJ
中科院分区：
文献类型：
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作者：
DELATORRE, JC;WIMMER, E;HOLLAND, JJ
我们仔细检查了1型脊髓灰质炎病毒胍依赖性突变体的6个不同克隆库中胍抗性回复突变体的频率。突变频率为（6.5 +/- 6.3）× 10（-4）（所有氨基酸取代均发生在位置227）。氨基酸227密码子中每个单核苷酸位点的最小校正碱基取代频率为（2.1 +/- 1.9）x 10（-4）。
We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9) x 10(-4).