Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats
Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats
复制标题
DOI：
10.1111/j.1469-7793.1999.829ad.x
复制
发表时间：
1999-02-01
影响因子：
5.5
通讯作者：
Mitchell, JH
中科院分区：
文献类型：
--
作者：
Potts, JT;Fuchs, IE;Mitchell, JH
1.在13只氯醛糖麻醉猫的心肺和骨骼肌受体激活过程中，利用体内微透析技术从孤束核（cNTS）连合部回收了速激肽P物质.通过刺激L7-S1腹根诱发强直性肌肉收缩（n=7）。电诱导的肌肉收缩使平均动脉压（MAP）增加55 +/- 10 mmHg，心率增加29 +/- g次/分（-1）。在收缩期间，透析液浓度比静息对照水平增加154%（从0.217+/-0.009到0.546 +/-0.023 fmol（100 μ l）（-1），对照与收缩，P
1. The tachykinin substance P was recovered from the commissural subdivision of the nucleus tractus solitarii (cNTS) using in vivo microdialysis during activation of cardiorespiratory and skeletal muscle receptors in thirteen chloralose-anaesthetized cats.2. Tetanic muscle contraction was evoked by stimulating L7-S1 ventral roots (n=7). Electrically induced muscle contraction increased mean arterial pressure (MAP) by 55 +/- 10 mmHg and heart rate by 29 +/- g beats min(-1). During contraction the dialysate concentration increased 154% above resting control levels (from 0.217+/-0.009 to 0.546 +/- 0.023 fmol(100 mu l)(-1), control vs. contraction, P