Antral atrophy, Helicobacter pylori colonization, and gastric pH.
Antral atrophy, Helicobacter pylori colonization, and gastric pH.
复制标题
DOI：
10.1093/ajcp/105.1.96
复制
发表时间：
1996
影响因子：
3.5
通讯作者：
B. Ruiz;P. Correa;E. Fontham;T. Ramakrishnan
中科院分区：
文献类型：
--
作者：
B. Ruiz;P. Correa;E. Fontham;T. Ramakrishnan
在多灶性萎缩性胃炎高发人群中研究幽门螺杆菌定植、胃粘膜炎症和萎缩的地形分布与空腹胃pH值之间的关系。胃窦萎缩的增加与胃窦本身幽门螺杆菌定植的减少有关，但与胃体定植的增加有关。晚期萎缩与高空腹胃pH值相关。然而，治疗性根除幽门螺杆菌后，炎症消退，胃pH值下降，表明尽管持续萎缩，酸分泌改善。作者提出，胃窦萎缩促进幽门螺杆菌在泌酸粘膜的定植，从而损害酸分泌并引起低氯血症，这可能进一步促进泌酸粘膜的定植。根除幽门螺杆菌可显著改善低氯血症。它可以恢复大多数患者的酸分泌，无论是否存在萎缩，这是一种可能对阻止胃癌发生过程非常有益的效果。
The association between the topographic distribution of Helicobacter pylori colonization, inflammation and atrophy of the gastric mucosa, and fasting gastric pH was studied in a population with high prevalence of multifocal atrophic gastritis. Increasing atrophy of the antrum was associated with decreasing H pylori colonization of the antrum itself, but increasing colonization of the corpus. Advanced atrophy was associated with high fasting gastric pH. However, after therapeutic eradication of H pylori, inflammation subsided and gastric pH decreased indicating improved acid secretion despite persistent atrophy. The authors propose that antral atrophy fosters the colonization of oxyntic mucosa by H pylori, thus impairing acid secretion and causing hypochlorhydria that may further promote colonization of the oxyntic mucosa. Eradication of H pylori significantly improves hypochlorhydria. It may restore acid secretion in most patients, regardless of the presence of atrophy, which is an effect that may be of great benefit in halting the process of gastric carcinogenesis.