The intrathymic pathogenesis of myasthenia gravis.
The intrathymic pathogenesis of myasthenia gravis.
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DOI：
10.1080/17402520400001769
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发表时间：
2004-09
影响因子：
--
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Levinson AI;Song D;Gaulton G;Zheng Y
胸腺被认为在重症肌无力的发病机制中起重要作用，重症肌无力是一种以抗体介导的骨骼肌无力为特征的自身免疫性疾病。然而，其作用尚未确定。本文所述的研究总结了我们的努力，以确定如何胸腺内表达的神经肌肉型乙酰胆碱（ACh）受体参与这种自身免疫性疾病的免疫发病机制。我们回顾了表征胸腺中神经肌肉ACh受体表达的工作，并提出了一个新的假设，即检查这种自身抗原在疾病发病机制中的胸腺内表达。
The thymus is considered to play an important role in the pathogenesis of Myasthenia gravis, an autoimmune disease characterized by antibody-mediated skeletal muscle weakness. However, its role is yet to be defined. The studies described herein summarize our efforts to determine how intrathymic expression of the neuromuscular type of acetylcholine (ACh) receptors is involved in the immunopathogenesis of this autoimmune disease. We review the work characterizing the expression of neuromuscular ACh receptors in the thymus and advance a new hypothesis that examines the intrathymic expression of this autoantigen in disease pathogenesis.