Ascorbic Acid Levels in Phagocytic Cells 1
Ascorbic Acid Levels in Phagocytic Cells 1
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吞噬细胞中的抗坏血酸水平 1
DOI：
10.3181/00379727-145-37974
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发表时间：
1974
影响因子：
--
通讯作者：
P. Shirley
中科院分区：
文献类型：
--
作者：
L. Dechatelet;C. McCall;M. Cooper;P. Shirley
测定豚鼠腹膜PMNL、正常家兔肺泡巨噬细胞、bcg诱导家兔肺泡巨噬细胞、家兔腹膜PMNL和人循环PMNL中抗坏血酸的浓度。高水平的抗坏血酸在所有类型的细胞中都被检测到，这与这种化合物在吞噬细胞的杀菌活性中的作用是一致的。慢性粒细胞白血病、真性红细胞增多症患者或一名慢性肉芽肿性疾病患者的白细胞与正常人无显著差异。
Summary The concentration of ascorbic: acid was determined in guinea pig peritoneal PMNL, normal rabbit alveolar macrophages, BCG-induced rabbit alveolar macrophages, rabbit peritoneal PMNL, and human circulating PMNL. The high levels of ascorbate seen in all cell types examined are consistent with a role for this compound in the bactericidal activity of the phagocytes. No significant differences from normal were observed in leukocytes from patients with chronic granulocytic leukemia, polycythemia vera, or in one patient with chronic granulomatous disease.