Progression rate of newly diagnosed impaired fasting glycemia to type 2 diabetes mellitus: A study using the National Healthcare Group Diabetes Registry in Singapore
Progression rate of newly diagnosed impaired fasting glycemia to type 2 diabetes mellitus: A study using the National Healthcare Group Diabetes Registry in Singapore
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DOI：
10.1111/j.1753-0407.2011.00169.x
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发表时间：
2012-06-01
影响因子：
4.5
通讯作者：
Heng, Bee Hoon
中科院分区：
文献类型：
--
作者：
Ang, Yee Gary;Wu, Christine Xia;Heng, Bee Hoon
背景资料：本研究的目的是估计新加坡新诊断的空腹血糖受损（IFG）进展为2型糖尿病（T2 DM）的比率，并确定与新诊断的IFG患者进展为T2 DM相关的因素。本研究是一项回顾性队列研究，对2006年1月1日至2008年12月31日期间在国家医疗保健集团糖尿病登记处新诊断的IFG进行了研究。和2007年12月31日，以估计进展为T2 DM的速率。单变量生存分析，然后进行多变量生存分析，并在最终的model.Results相互作用进行了测试：在一个平均随访期为1.65 +/- 0.13年，85的490名参与者与新诊断IFG开发T2 DM，给6.8%的年进展率。与2型糖尿病发生相关的因素是IFG诊断当年空腹血糖水平较高（风险比[HR] = 14.6; 95%置信区间[CI] 5.66-37.5），中国人种（HR = 2.70; 95%CI 1.44-5.06）和体重指数（HR = 1.11; 95%CI 1.06-1.15）。结论：初诊IFG患者进展为T2 DM的几率较高。强化的生活方式改变可以纳入他们目前的年度随访，以防止进展为2型糖尿病，这是一个日益严重的问题，在新加坡。
Background: The aims of the present study were to estimate the rate of progression from newly diagnosed impaired fasting glycemia (IFG) to type 2 diabetes mellitus (T2DM) in Singapore and to identify factors associated with the progression to T2DM in individuals with newly diagnosed IFG.Methods: The present study was a retrospective cohort study of newly diagnosed IFG from the National Healthcare Group Diabetes Registry between 1 January 2006 and 31 December 2007 to estimated the rate of progression to T2DM. Univariate survival analysis, followed by multivariate survival analysis, was performed and interactions were tested in the final model.Results: Over a mean follow-up period of 1.65 +/- 0.13 years, 85 of 490 participants with newly diagnosed IFG developed T2DM, giving an annual progression rate of 6.8%. The factors associated with the development of T2DM were higher fasting plasma glucose level in the year of IFG diagnosis (hazard ratio [HR] = 14.6; 95% confidence interval [CI] 5.66-37.5), Chinese race (HR = 2.70; 95% CI 1.44-5.06), and body mass index (HR = 1.11; 95% CI, 1.06-1.15).Conclusions: The progression rate to T2DM is high in subjects with newly diagnosed IFG. Intensive lifestyle modification can be incorporated into their current yearly follow-up to prevent progression to T2DM, which is a growing problem in Singapore.