DEMYELINATING LESIONS DUE TO THEILER VIRUS ARE ASSOCIATED WITH ONGOING CENTRAL-NERVOUS-SYSTEM INFECTION
DEMYELINATING LESIONS DUE TO THEILER VIRUS ARE ASSOCIATED WITH ONGOING CENTRAL-NERVOUS-SYSTEM INFECTION
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DOI：
10.1128/jvi.57.3.992-997.1986
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发表时间：
1986-03-01
影响因子：
5.4
通讯作者：
BRAHIC, M
中科院分区：
文献类型：
--
作者：
CHAMORRO, M;AUBERT, C;BRAHIC, M
我们使用原位杂交和免疫细胞化学来寻找由于持续泰勒病毒感染导致的晚期脱髓鞘疾病期间病毒表达与白质病变之间的相关性。我们发现了以下内容。 (i) 病毒感染部位出现组织损伤。这种相关性不能用淋巴细胞和巨噬细胞的感染来解释。 (ii)小鼠之间的病理程度存在很大差异。炎症的数量与含有病毒RNA或病毒衣壳抗原的细胞数量平行。 (iii) 对脱髓鞘具有抵抗力的 C57BL/6 小鼠能够根除感染。我们的结果强烈支持脱髓鞘机制，其中病毒基因产物发挥核心作用。
We used in situ hybridization and immunocytochemistry to look for a correlation between virus expression and white matter lesions during late demyelinating disease due to persistent Theiler''s virus infection. We found the following. (i) Tissue lesions developed at the site of virus infection. This correlation was not explained by infection of lymphocytes and macrophages. (ii) Large differences in the extent of pathology existed between mice. The amount of inflammation paralleled the number of cells containing viral RNA or viral capsid antigens. (iii) C57BL/6 mice, which are resistant to demyelination, were able to eradicate the infection. Our results are strongly in favor of a mechanism of demyelination in which viral gene products play a central role.