MEASUREMENT OF ACUTE TOLERANCE TO ALCOHOL IN HUMAN-SUBJECTS
MEASUREMENT OF ACUTE TOLERANCE TO ALCOHOL IN HUMAN-SUBJECTS
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DOI：
10.1111/j.1530-0277.1993.tb00751.x
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发表时间：
1993-04-01
影响因子：
3.2
通讯作者：
MOSS, HB
中科院分区：
文献类型：
--
作者：
MARTIN, CS;MOSS, HB
急性耐受性可以定义为单次接触药物后对酒精的反应降低，其发生与血液酒精浓度（BAC）的变化无关。在大多数人类饮酒研究中，BAC 会随着时间的推移而变化，必须使用解释这些变化的计算技术来测量急性耐受性发展的速率。人类研究中最广泛使用的急性耐受性测量通常称为梅兰比效应，涉及比较相同 BAC 下血液酒精曲线上升和下降肢体的反应。我们将梅兰比测量与其他两种盾片耐受性测量进行了比较：概念上相似的曲线下面积测量，以及仅使用来自血液酒精曲线下降肢的数据的斜率函数方法。这些措施是相互关联的，并就经验和概念问题进行了讨论。据报道，对有和没有酗酒家族史的人进行了探索性比较。提出了计算急性耐受性的方法学建议。研究结果提出了测量急性耐受性获得率的新方法，并提出了耐受倾向和酗酒风险的未来研究领域。
Acute tolerance can be defined as a decrease in response to alcohol within a single exposure to the drug, which occurs independently of changes in blood alcohol concentrations (BACs). BACs change over time in most human alcohol administration studies, and computational techniques that account for these changes must be used to measure the rate of acute tolerance development. The most widely used acute tolerance measure in human research is often called the Mellanby effect, and involves the comparison of responses at the same BAC on the ascending and descending limbs of the blood alcohol curve. We compared the Mellanby measure with two other measures of scute tolerance: a conceptually similar area under the curve measure, and a slope function approach that used data only from the descending limb of the blood alcohol curve. The measures were intercorrelated and discussed with regard to empirical and conceptual issues. Exploratory comparisons of those with and without a family history of alcoholism are reported. Methodological recommendations for the computation of acute tolerance are made. The results suggest new methods for measuring the rate of acquisition of acute tolerance, and suggest areas for future research on tolerance-proneness and risk for alcoholism.