Molecular-matched materials for anticancer drug delivery and imaging.
Molecular-matched materials for anticancer drug delivery and imaging.
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DOI：
10.2217/nnm.15.117
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发表时间：
2015-09
期刊：
影响因子：
5.5
通讯作者：
Dun Wang;Q. Fu;Jingling Tang;Michael J. Hackett;Yongjun Wang;Feng Liu
中科院分区：
文献类型：
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作者：
Dun Wang;Q. Fu;Jingling Tang;Michael J. Hackett;Yongjun Wang;Feng Liu
目的在本研究中，我们的目标是构建具有高载量和受控血清动力学的纳米制剂。材料与方法分子匹配材料（MMM）是通过将功能部分缀合到代表纳米颗粒核心的分子上来建立的。使用MMM制备分子匹配的纳米乳和脂质体。结果这种基于MMM的技术甚至允许我们有效地将疏水或亲水部分负载到纳米颗粒的疏水核中。基于MMMs的纳米粒显示出显著的改善血清药代动力学和抗癌效果。结论当PEG衍生物的疏水性锚和与治疗（或成像）剂偶联的部分与核的分子结构相同时，可以获得所需的性能。
AIM In this study, we aim to construct nanoformulation with high-cargo loading and controlled serum kinetics. MATERIALS & METHODS Molecular-matched materials (MMMs) are established through the conjugation of the functional moiety to a molecule representative of the nanoparticle's core. Molecular-matched nanoemulsions and liposomes were prepared using MMMs. RESULTS This technique based on MMMs even allows us to efficiently load either hydrophobic or hydrophilic moieties into a hydrophobic core of the nanoparticles. MMMs-based nanoparticles showed marked improvement in serum pharmacokinetics and anticancer effect. CONCLUSION The desired performance can be achieved when the hydrophobic anchor of the PEG derivatives and the moiety conjugated to the therapeutic (or imaging) agents are molecularly identical to the core.