Regulation of Smad signalling by protein associations and signalling crosstalk.
Regulation of Smad signalling by protein associations and signalling crosstalk.
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DOI：
10.1016/s0962-8924(99)01579-2
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发表时间：
1999-07
影响因子：
19
通讯作者：
Ying Zhang;R. Derynck
中科院分区：
文献类型：
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作者：
Ying Zhang;R. Derynck
Smads是转化生长因子β (TGF-β)相关生长和分化因子家族的细胞内信号介质，通过跨膜丝氨酸/苏氨酸激酶发出信号。在受体诱导激活后，异质Smad复合物转运到细胞核中，在那里它们充当转录因子。最近的研究表明，Smad信号不仅由TGF-β受体的激活决定，而且还通过与其他激酶信号级联的串扰进行调节。此外，smad通过与其他转录因子的功能协同和物理相互作用来调节转录，这也可能是其他信号级联调节的靶点。这种信号串扰可能解释了对TGF-β和相关因子反应的复杂性。
Smads are intracellular signalling mediators for the family of transforming growth factor β (TGF-β)-related growth and differentiation factors, which signal through transmembrane serine/threonine kinases. Following receptor-induced activation, heteromeric Smad complexes translocate into the nucleus, where they act as transcription factors. Recent progress has revealed that Smad signalling is not merely determined by activation of the class of TGF-β receptors, but is also regulated through crosstalk with other kinase signalling cascades. In addition, the Smads regulate transcription through functional cooperativity and physical interactions with other transcription factors, which might also be targets for regulation by other signalling cascades. This signalling crosstalk might explain the complexity of the responses to TGF-β and related factors.