Chemistry and Biology of Multicomponent Reactions
Chemistry and Biology of Multicomponent Reactions
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DOI：
10.1002/chin.201234225
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发表时间：
2012-08
期刊：
影响因子：
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通讯作者：
A. Dömling;Wei Wang;Kan Wang
中科院分区：
文献类型：
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作者：
A. Dömling;Wei Wang;Kan Wang
多组分反应（MCRs）是一锅反应，使用两种以上的起始物质，例如3,4，…， 7，其中大部分的起始材料的原子被纳入最终产品。(1)几个描述性标签通常附在mcr上（图1）：它们是原子经济的，例如，大部分（如果不是全部）起始材料的原子都被纳入产品中；它们是有效的，例如，它们有效地产生产品，因为产品是一步形成的，而不是多个连续的步骤；它们是收敛的，例如，几种起始物质在一次反应中结合形成产物；它们表现出非常高的成键指数（BFI），例如，在一次合成转化中可以形成几个非氢原子键。因此，mcr通常是顺序多步合成的有用替代方案。
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are incorporated in the final product.(1) Several descriptive tags are regularly attached to MCRs (Figure 1): they are atom economic, for example, the majority if not all of the atoms of the starting materials are incorporated in the product; they are efficient, for example, they efficiently yield the product since the product is formed in one-step instead of multiple sequential steps; they are convergent, for example, several starting materials combine in one reaction to form the product; they exhibit a very high bond-forming-index (BFI), for example, several non-hydrogen atom bonds are formed in one synthetic transformation.(2) Therefore MCRs are often a useful alternative to sequential multistep synthesis.