Tackling the emerging threat of antifungal resistance to human health.
Tackling the emerging threat of antifungal resistance to human health.
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DOI：
10.1038/s41579-022-00720-1
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
Verweij PE
中科院分区：
文献类型：
--
作者：
Fisher MC;Alastruey-Izquierdo A;Berman J;Bicanic T;Bignell EM;Bowyer P;Bromley M;Brüggemann R;Garber G;Cornely OA;Gurr SJ;Harrison TS;Kuijper E;Rhodes J;Sheppard DC;Warris A;White PL;Xu J;Zwaan B;Verweij PE
侵袭性真菌感染对公共健康构成了重要威胁，并且是抗菌素耐药性这一全球新兴危机的一个未被充分认识的组成部分。在全球环境发生深刻变化和高危人群不断扩大的时期，感染人类的病原真菌正在对所有获得许可的全身抗真菌药物产生耐药性。在这篇综述中，我们重点介绍了抗真菌耐药性的主要机制，并探讨了细菌和真菌对抗菌药物控制耐药性的异同。我们讨论旨在最大限度地减少病原真菌抗性出现的风险降低策略所需的研究和创新主题。这些主题包括环境与“同一个健康”之间的联系、监测、诊断、传播途径、新疗法和减轻真菌适应热点的方法。我们强调需要全球努力来管理我们现有的抗真菌药物，并指导未来疗法和干预措施的研究和开发。真菌感染对人类健康的影响日益受到关注，病原真菌对所有获得许可的全身抗真菌药物的耐药性已被记录。在这篇综述中，Fisher、Verweij 及其同事讨论了了解和尽量减少抗真菌耐药性的发生和影响所需的研究和创新主题。
Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a period of profound global environmental change and expanding at-risk populations, human-infecting pathogenic fungi are evolving resistance to all licensed systemic antifungal drugs. In this Review, we highlight the main mechanisms of antifungal resistance and explore the similarities and differences between bacterial and fungal resistance to antimicrobial control. We discuss the research and innovation topics that are needed for risk reduction strategies aimed at minimizing the emergence of resistance in pathogenic fungi. These topics include links between the environment and One Health, surveillance, diagnostics, routes of transmission, novel therapeutics and methods to mitigate hotspots for fungal adaptation. We emphasize the global efforts required to steward our existing antifungal armamentarium, and to direct the research and development of future therapies and interventions. The impacts of fungal infections on human health are of increasing concern, and resistance of pathogenic fungi to all licensed systemic antifungals has been documented. In this Review, Fisher, Verweij and colleagues discuss the research and innovation topics that are needed to understand and minimize the occurrence and impact of antifungal resistance.
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DOI：
10.1016/j.fgb.2018.02.003
发表时间：
2018-04
期刊：
Fungal genetics and biology : FG & B
影响因子：
--
作者：
Ballard E;Melchers WJG;Zoll J;Brown AJP;Verweij PE;Warris A
通讯作者：
Warris A
影响因子：
6.4
作者：
Boyce, Kylie J.;Wang, Yina;Idnurm, Alexander
通讯作者：
Idnurm, Alexander
影响因子：
7.7
作者：
Billmyre, R. Blake;Clancey, Shelly Applen;Heitman, Joseph
通讯作者：
Heitman, Joseph
影响因子：
3.9
作者：
Argimón S;Abudahab K;Goater RJE;Fedosejev A;Bhai J;Glasner C;Feil EJ;Holden MTG;Yeats CA;Grundmann H;Spratt BG;Aanensen DM
通讯作者：
Aanensen DM
影响因子：
6.7
作者：
Burks C;Darby A;Gómez Londoño L;Momany M;Brewer MT
通讯作者：
Brewer MT