STUDY OF BIOLOGICAL EFFECTS OF TRITIUM IN MICE
STUDY OF BIOLOGICAL EFFECTS OF TRITIUM IN MICE
复制标题
氚对小鼠生物学效应的研究
DOI：
10.1093/rpd/ncac055
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发表时间：
2022
影响因子：
1
通讯作者：
Umata Toshiyuki
中科院分区：
文献类型：
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作者：
立花 優;野上 雅伸;阿部 達雄;Umata Toshiyuki
本文研究了氚水对小鼠脾T淋巴细胞的致突变、细胞凋亡和染色体畸变率，并与急性期和慢性期137Cs照射的小鼠进行了比较。野生型(p53+/+)和空(p53−/−)小鼠一次注射氚(~3H)β射线，剂量率为0.86Gymin−1(急性)，低剂量率(0.71~0.09mGymin−1)模拟内照射(伽马射线模拟照射)。每一次照射剂量为3Gy.在3GyP53-−/−小鼠诱发的TcR变异组分的基础上进行比较时，~3H-β射线似乎比慢性伽玛射线参考值更具诱变性。另一方面，注射HTO的小鼠和137Cs照射的小鼠的染色体畸变率没有显著差异。
The mutation, apoptosis and chromosomal aberration induced by tritiated water (HTO) in spleen T lymphocytes of mice were investigated and compared with those by acute or chronic137Cs gamma irradiation.p53wild-type (p53+/+) and null (p53−/−) mice were exposed to tritium (3H) beta rays via a single injection of HTO.137Cs gamma irradiation was carried out at dose-rate of 0.86Gy min−1(acute) and at a low dose-rate (0.71–0.09 mGy min−1) that mimicked internal exposure (gamma simulation-irradiation). Each dose of irradiation was 3Gy. When compared on the basis of the induced TCR variant fractions inp53−/−mice at 3Gy,3H beta rays appeared to be more mutagenic than chronic gamma ray reference. On the other hand, both of the frequency chromosomal aberration was not different significantly between HTO injected and137Cs gamma irradiated mice.