Infection control in gene therapy
Infection control in gene therapy
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DOI：
10.1086/501674
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发表时间：
1999-08-01
影响因子：
4.5
通讯作者：
Lesnaw, JA
中科院分区：
文献类型：
--
作者：
Evans, ME;Lesnaw, JA
目前正在研究基因疗法，以治疗各种各样的获得性和遗传性疾病。用作基因转移载体的病毒包括逆转录病毒、腺病毒、牛痘病毒、腺相关病毒和疱疹病毒。这些在实验室和动物研究中开发的病媒现在正被引入临床领域。感染控制从业人员将始终参与审查这些药物在其诊所和医院的使用情况。本综述总结了较为常见的病媒的主要方面，并对感染控制提出了建议。
Gene therapy is now being studied for the treatment of a wide variety of acquired and inherited diseases. Viruses used as vectors for gene transfer include retroviruses, adenoviruses, vaccinia viruses, adeno-associated viruses, and herpesviruses. These vectors, developed in the laboratory and in animal studies, are now being introduced into the clinical arena. Infection control practitioners will be involved invariably in reviewing the use of these agents in their clinics and hospitals. This review summarizes key aspects of the more common vectors and makes recommendations for infection control.