Effect of gestational age and birth weight on tobramycin kinetics in newborn infants.
Effect of gestational age and birth weight on tobramycin kinetics in newborn infants.
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胎龄和出生体重对新生儿妥布霉素动力学的影响。
DOI：
10.1093/jac/14.1.59
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Glazer
中科院分区：
文献类型：
--
作者：
M. Nahata;D. Powell;D. E. Durrell;M. C. Miller;J. Glazer
在26名出生后第一周内患有假定或证实的细菌性败血症的新生儿中研究了胎龄和出生体重对妥布霉素动力学的影响。婴儿接受妥布霉素2.5 mg/kg静脉注射，每12 h一次。A组包括9例孕龄28 - 30周的患者; B组有11例大于30至小于或等于34周的患者; C组有6例大于34至小于或等于40周的患者。A、B和C组妥布霉素的稳态血清峰浓度平均为6.5、7.2和7.1 mg/l;相应的谷浓度平均为2.0、2.3和1.3 mg/l。妥布霉素血清谷浓度> 2 mg/l的发生率A组为44%，B组为45%，C组为0%。A、B和C组妥布霉素的总体清除率平均为1.04、1.13和1.28 ml/min/kg;表观分布容积平均为0.84、0.81和0.61 l/kg;消除半衰期平均为9.3、8.9和5.6 h。M组包括7名出生体重为1.0-1.25 kg的婴儿; N组包括6名出生体重为1.26-1.50 kg的婴儿; O组包括7名出生体重为1.51-2.0 kg的婴儿; P组包括6名出生体重为2.1-3.5 kg的婴儿。M、N、O和P组妥布霉素的稳态血清峰浓度平均值为5.7、7.3、7.8和7.1 mg/l;血清谷浓度平均值为2.2、2.4、1.9和1.3 mg/l。（250字处删节）
The effects of gestational age and birth weight on tobramycin kinetics were studied in 26 newborn infants with presumed or proven bacterial sepsis during the first week of postnatal age. The infants received tobramycin, 2.5 mg/kg intravenously every 12 h. Group A consisted of nine patients 28 to 30 weeks of gestational age; group B had 11 patients greater than 30 to less than or equal to 34 weeks of gestational age; and group C had six patients greater than 34 to less than or equal to 40 weeks of gestational age. Steady-state peak serum concentrations of tobramycin averaged 6.5, 7.2 and 7.1 mg/l in groups A, B and C; the corresponding trough concentration averaged 2.0, 2.3 and 1.3 mg/l. The frequency of tobramycin trough serum concentration above 2 mg/l was 44% in group A, 45% in group B and 0% in group C. Total body clearance of tobramycin averaged 1.04, 1.13 and 1.28 ml/min/kg; apparent volume of distribution averaged 0.84, 0.81 and 0.61 l/kg; and elimination half-life averaged 9.3, 8.9 and 5.6 h in groups A, B and C. Group M consisted of seven infants with 1.0-1.25 kg birth weight; group N had six infants 1.26-1.50 kg birth weight; group O had seven infants 1.51-2.0 kg birth weight; and group P had six infants 2.1-3.5 kg birth weight. Steady-state peak serum concentration of tobramycin averaged 5.7, 7.3, 7.8 and 7.1 mg/l; and the trough serum concentration averaged 2.2, 2.4, 1.9 and 1.3 mg/l in groups M, N, O and P.(ABSTRACT TRUNCATED AT 250 WORDS)