Kinetics of intravenously administered 15N-L-alanine in the evaluation of protein turnover.
Kinetics of intravenously administered 15N-L-alanine in the evaluation of protein turnover.
复制标题
静脉注射 15N-L-丙氨酸在评估蛋白质周转中的动力学。
DOI：
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发表时间：
1979
影响因子：
7.1
通讯作者：
J. Kinney
中科院分区：
文献类型：
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作者：
M. Jeevanandam;C. Long;J. Kinney
在对健康男性受试者脉冲注射15 N-L-丙氨酸后，测定15 N在血液和尿液的各种组分中的分布作为时间的函数。同位素在尿尿素和氨以及血浆酰胺和尿素中的快速出现表明，转氨作用（而不是脱氨作用）可能是相互作用的关键步骤。注射后30至60分钟后，示踪剂动力学代表了整体代谢池的特征，并不只反映丙氨酸的代谢。丙氨酸中的氮被有效地用于身体蛋白质的合成。
After a pulse injection of 15N-L-alanine to a healthy male subject, the distribution of 15N in the various components of blood and urine were determined as function of time. The rapid appearance of the isotope both in the urinary urea and ammonia and in the plasma amide and urea suggests that transamination (and not deamination) may be the key step in the interaction. After 30 to 60 min postinjection, the tracer dynamics represents the overall metabolic pool characteristics and does not reflect the metabolism of alanine only. The nitrogen of alanine is used effectively in the synthesis of body protein.