Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls
Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls
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DOI：
10.1016/j.schres.2005.05.017
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发表时间：
2005-10-15
影响因子：
4.5
通讯作者：
Candela, S
中科院分区：
文献类型：
--
作者：
Maher, BA;Manschreck, TC;Candela, S
背景资料：联想对精神分裂症患者话语的干扰通常会破坏患者话语的连贯性。最近对这些现象的理论阐述强调了这种语言干扰中联想网络的过度活跃（例如，马赫，文学士2003精神分裂症，异常的话语和控制妄想：言语和思想的分离，以及经验和信仰的联系。《语言与思想》，18，1-22。一直只有有限的努力来量化这些功能在patient population.Methods：我们假设（1）连贯的话语引起的精神分裂症患者的样本将提出一个更高的平均频率的规范协会比正常对照组;和（2）有一个正相关的总协会之间的话语和超联想活动（积极促进）的语义启动任务评估。研究对象包括43名精神分裂症患者和25名健康对照者。三项措施，一个新的计算机程序，计算关联序列文本（CAST），以量化规范协会;图片描述技术引发的语音样本;和语义启动任务，以衡量联想facilitation.Results：在连贯的话语，精神分裂症患者产生较高的平均总协会相比，控制。在语义启动程序的控制加工间隔（1250 ms）内，促进得分为正的患者，促进得分与总联想频率之间存在相关性。这种效果是不存在的controls.Conclusions：这些结果是一致的精神分裂症的语言障碍，联想网络的过度活跃的模型。(c)2005 Elsevier B.V保留所有权利。
Background: The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance {e.g., Maher, B.A. 2003 Schizophrenia, aberrant utterance and delusions of control: the disconnection of speech and thought, and the connection of experience and belief. Mind and Language, 18, 1-22}. There has been only limited effort to quantify such features in patient populations.Methods: We hypothesized that (1) coherent utterances elicited from a sample of schizophrenia patients will present a higher mean frequency of normative associations than in normal controls; and (2) there is a positive association between total associations in utterances and hyperassociative activity (positive facilitation) as assessed by a semantic priming task. Participants included 43 schizophrenic patients and 25 healthy controls. Three measures were employed, a new computer program, Computed Associations in Sequential Text (CAST), to quantify normative associations; a picture description technique for eliciting speech samples; and a semantic priming task to measure associative facilitation.Results: In coherent utterances, schizophrenia patients produced higher mean totals of associations compared to controls. Patients with positive facilitation scores in the controlled processing interval (1250 ms) of the semantic priming procedure, there was a correlation between facilitation scores and total frequency of associations. This effect was absent in controls.Conclusions: These results are consistent with models of language disturbance in schizophrenia that posit hyperactivity of associational networks. (c) 2005 Elsevier B.V All rights reserved.