Digitized cerebral synchrotron radiation angiography: quantitative evaluation of the canine circle of Willis and its large and small branches.
Digitized cerebral synchrotron radiation angiography: quantitative evaluation of the canine circle of Willis and its large and small branches.
复制标题
数字化脑同步辐射血管造影：威利斯犬圈及其大小分支的定量评估。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
H. Mori
中科院分区：
文献类型：
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作者：
E. Tanaka;A. Tanaka;T. Sekka;Y. Shinozaki;K. Hyodo;K. Umetani;H. Mori
背景和目的
传统的X射线血管造影术缺乏检测少量碘化造影剂和定量脑内小血管直径所需的灵敏度和空间分辨率。本研究的目的是确定数字化同步辐射微血管造影术，使用高清晰度电视摄像系统，可以准确地显示小脑血管。
方法
将6只麻醉犬暴露于单色同步辐射，能量水平为33.3 keV，用于碘检测，同时将碘化造影剂注入头臂动脉和椎动脉。这些图像是用空间分辨率为30微米的高清晰度电视摄像系统检测的。共获得Willis环及其分支的脑血管造影片26张，并在工作站上进行数字化。
结果
Willis环的小分支在所有图像上都清晰可见。在图像上定量证实了CO2吸入引起的Willis环及其大小分支的血管扩张：例如，一个小分支的直径从0.24 +/- 0.04 mm增加到0.38 +/- 0.12 mm。
结论
同步辐射血管造影系统可用于显示大脑深处的大小血管以及定量其直径。
BACKGROUND AND PURPOSE
Conventional X-ray angiography lacks the sensitivity and spatial resolution needed to detect small amounts of iodinated contrast material and to quantitate diameters of the small vessels in the brain. The purpose of this study was to ascertain whether digitized synchrotron radiation microangiography, with the use of a high-definition TV camera system, can accurately show small cerebral vessels.
METHODS
Six anesthetized dogs were exposed to monochromatic synchrotron radiation with an energy level of 33.3 keV optimized for iodine detection while iodinated contrast material was injected into the brachiocephalic and vertebral arteries. The images were detected with a high-definition TV camera system with a spatial resolution of 30 microm. In all, 26 cerebral angiograms of the circle of Willis with its branches were obtained, and the images were digitized at a workstation.
RESULTS
The small branches of the circle of Willis were clearly visible on all images. Vasodilatation of the circle of Willis and its large and small branches induced by CO2 inhalation was quantitatively confirmed on the images: for example, the diameter of one small branch was increased from 0.24 +/- 0.04 mm to 0.38 +/- 0.12 mm. Temporal subtraction improved the image quality.
CONCLUSION
The synchrotron radiation angiographic system is useful for visualizing large and small vessels deep in the brain as well as for quantitating their diameters.