Serine proteinase inhibitors in arthropod immunity
Serine proteinase inhibitors in arthropod immunity
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DOI：
10.1016/s0145-305x(99)00012-9
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发表时间：
1999-06-01
影响因子：
2.9
通讯作者：
Kanost, MR
中科院分区：
文献类型：
--
作者：
Kanost, MR
节肢动物血淋巴含有丝氨酸蛋白酶抑制活性的蛋白质。这些抑制剂可能存在于血浆或血细胞颗粒中。丝氨酸蛋白酶抑制剂来自哈萨克族。Kunitz、α-巨球蛋白和丝氨酸蛋白酶抑制剂家族已在节肢动物血淋巴中鉴定，并已进行生化表征。最近发现了两个新的低分子量丝氨酸蛋白酶抑制剂家族：一个在蚕中（家蚕家族），另一个在蝗虫和小龙虾中。节肢动物血淋巴中的丝氨酸蛋白酶抑制剂可能具有保护宿主免受病原体或寄生虫感染的功能。有些可能会抑制真菌或细菌蛋白酶。其他可能有调节内源性蛋白酶参与凝血，酚氧化酶激活，或细胞因子激活的作用。(C)1999 Elsevier Science Ltd.保留所有权利。
Arthropod hemolymph contains proteins with serine proteinase inhibitory activity. These inhibitors may exist in plasma or in hemocyte granules. Serine proteinase inhibitors from the Kazal. Kunitz, alpha-macroglobulin, and serpin families have been identified in arthropod hemolymph and have been characterized biochemically. Two new families of low molecular weight serine proteinase inhibitors have recently been discovered: one in silkworms (the Bombyx family) and another in locusts and a crayfish. The serine proteinase inhibitors in arthropod hemolymph are likely to function in protecting their hosts from infection by pathogens or parasites. Some may inhibit fungal or bacterial proteinases. Others probably have roles in regulating endogenous proteinases involved in coagulation, prophenol oxidase activation, or cytokine activation. (C) 1999 Elsevier Science Ltd. All rights reserved.