Atrial natriuretic factor inhibits Na-K-Cl cotransport in teleost intestine.
Atrial natriuretic factor inhibits Na-K-Cl cotransport in teleost intestine.
复制标题
心房钠尿因子抑制硬骨鱼肠道中的 Na-K-Cl 共转运。
DOI：
10.1152/ajpcell.1985.249.5.c531
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Rao,MC
中科院分区：
文献类型：
--
作者：
O'Grady,SM;Field,M;Nash,NT;Rao,MC
在硬骨鱼对侧肠黏膜中加入心钠素(ANF)，可抑制短路电流、钠和氯的净跨上皮通量以及Rb在刷状缘膜上的单向流入。加入8-溴鸟苷3‘，5’-环一磷酸(8-BrcGMP)可以很好地模拟ANF的这一作用。与肠道不同，体外添加ANF或8-BrcGMP后，牙槽鱼的顶盖上皮不产生反应。因为当海水鱼进入较低盐度的水中时，肠道对盐和水的吸收会减少，ANF可能是一种重要的激素调节因子，通过它，泛盐鱼类可以适应不同的盐度。
Addition of atrial natriuretic factor (ANF) to the contraluminal side of the intestinal mucosa of a marine teleost, the winter flounder Pseudopleuronectes americanus, inhibits short-circuit current, net transepithelial fluxes of Na and Cl, and the unidirectional influx of Rb across the brush border membrane. This action of ANF is closely mimicked by addition of 8-bromo-guanosine 3',5'-cyclic monophosphate (8-BrcGMP). In contrast to the intestine, the opercular epithelium of the flounder did not respond to the in vitro addition of either ANF or 8-BrcGMP. Because intestinal salt and water absorption diminishes when marine fish enter water of lower salinity, ANF may be an important hormonal regulator through which euryhaline fish adapt to varying salinities.