Molecular Cancer Cytotoxic Effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (aicar) on Childhood Acute Lymphoblastic Leukemia (all) Cells: Implication for Targeted Therapy
Molecular Cancer Cytotoxic Effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (aicar) on Childhood Acute Lymphoblastic Leukemia (all) Cells: Implication for Targeted Therapy
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通讯作者：
T. Sengupta;Gilles M. Leclerc;Ting Ting Hsieh-Kinser-Ting;Guy J Leclerc;I. Singh;J. Barredo;Email Tapas;Gilles;Ting Ting-Ting
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作者：
T. Sengupta;Gilles M. Leclerc;Ting Ting Hsieh-Kinser-Ting;Guy J Leclerc;I. Singh;J. Barredo;Email Tapas;Gilles;Ting Ting-Ting
背景：急性淋巴细胞白血病(ALL)是儿童最常见的血液系统恶性肿瘤。尽管在治疗急性淋巴细胞白血病方面取得了重大进展和成功，但仍有相当数量的儿童继续复发，对他们来说，结果仍然很差。因此，寻找新的治疗方法是必要的。本研究的目的是研究AMP活化蛋白激酶(AMPK)作为儿童急性淋巴细胞白血病(ALL)的潜在靶点，该亚型具有非随机易位特征。我们评估了AMPK激活剂AICAR对各种儿童ALL细胞的细胞生长、细胞周期调节和凋亡的影响。
Background: Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to relapse and for them, outcome remains poor. Therefore, the search for novel therapeutic approaches is warranted. The aim of this study was to investigate the AMP activated protein kinase (AMPK) as a potential target in childhood acute lymphoblastic leukemia (ALL) subtypes characterized by non-random translocation signature profiles. We evaluated the effects of the AMPK activator AICAR on cell growth, cell cycle regulators and apoptosis of various childhood ALL cells.