Do Depressive Symptoms and Gait Speed Impairment Predict Each Other's Incidence? A 16-Year Prospective Study in the Community
Do Depressive Symptoms and Gait Speed Impairment Predict Each Other's Incidence? A 16-Year Prospective Study in the Community
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DOI：
10.1111/j.1532-5415.2012.04114.x
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发表时间：
2012-09-01
影响因子：
6.3
通讯作者：
Beekman, Aartjan T. F.
中科院分区：
文献类型：
--
作者：
Sanders, Joost B.;Bremmer, Marijke A.;Beekman, Aartjan T. F.
目的探讨步速是否能预测抑郁症状的发生，以及抑郁症状是否能预测步速障碍的发生；确定这些关联的共同危险因素的存在。设计阿姆斯特丹纵向衰老研究，这是一项前瞻性队列研究，有5个随访周期，超过16年。设置基于人口。参与者：1228名调查对象有抑郁症状（平均年龄68.9，类似于+/-类似于8.5），1855名调查对象有步态速度障碍（平均年龄68.0，类似于+/-类似于8.2）。使用流行病学研究中心抑郁量表测量抑郁症状；在步行3米的过程中，以尽可能快的速度来回测量步态速度，并进行180度转弯。使用Cox回归对两性进行多变量分析。结果24%的被调查者出现抑郁症状。在单变量分析中，基线时的步速预测了男性和女性抑郁症状的发生；调整协变量后，这种关联仅在男性中存在。通过研究相反的关联，34%的受访者出现了步态速度障碍。女性基线时的抑郁症状与偶发的步速损害有单因素相关，而男性无；这种关联在调整后不存在。双向关联并不具有相同的解释变量。结论步态速度可预测男性抑郁症状。老年抑郁症症状和晚年步态减慢似乎是由不同的病理造成的，因此这两种疾病都需要各自的治疗策略。
Objectives To investigate whether gait speed predicts incident depressive symptoms and whether depressive symptoms predict incident gait speed impairment; to ascertain the presence of shared risk factors for these associations. Design The Longitudinal Aging Study Amsterdam, a prospective cohort study with five follow-up cycles over 16 similar to years. Setting Population based. Participants One thousand nine hundred twenty-eight respondents for incident depressive symptoms (mean age 68.9 similar to +/-similar to 8.5) and 1,855 respondents for incident gait speed impairment (mean age 68.0 similar to +/-similar to 8.2). Measurements Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale; gait speed was measured, back and forth, during a 3-m walk as quickly as possible, with a 180 degrees turn. Multivariate analyses were performed for both sexes using Cox regression. Results Incident depressive symptoms occurred in 24% of respondents. In univariate analyses, gait speed at baseline predicted incident depressive symptoms in men and women; after adjustment for covariates, this association persisted in men only. Examining the reverse association, 34% of respondents developed gait speed impairment. Depressive symptoms at baseline were univariately associated with incident gait speed impairment in women but not in men; this association did not persist after adjustment. The bidirectional associations did not share the same explanatory variables. Conclusion Gait speed predicts depressive symptoms in men. The geriatric giants of depressive symptoms and slowed gait speed in late life appear to result from different pathologies, both of which therefore require their own treatment strategies.