Anti-hyperalgesic effects of tramadol in the rat
Anti-hyperalgesic effects of tramadol in the rat
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DOI：
10.1016/s0006-8993(98)00388-6
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发表时间：
1998-06-22
期刊：
影响因子：
2.9
通讯作者：
Panerai, AE
中科院分区：
文献类型：
--
作者：
Bianchi, M;Panerai, AE
采用一种新的简单的行为学方法评价曲马多的抗大鼠痛觉过敏作用。在最低剂量（1.25 mg/kg i. p.）下，曲马多不改变热伤害性阈值，但能够预防和阻断由福尔马林尾部注射诱导的热后爪痛觉过敏。我们的研究结果提供的证据表明，曲马多块痛觉过敏的行为，而不改变伤害性感受，这表明这种镇痛药物可能是一个有效的代理对中央敏化。(C)1998 Elsevier Science B. V.保留所有权利。
A new simple behavioral method was used for the evaluation of the anti-hyperalgesic properties of tramadol in the rat. At the lowest dose (1.25 mg/kg i.p.), tramadol did not modify thermal nociceptive thresholds, but it was able to prevent and block thermal hindpaw hyperalgesia induced by the tail injection of formalin. Our results provide evidence that tramadol blocks hyperalgesic behaviors without altering nociception, suggesting that this analgesic drug might represent a valid agent against central sensitization. (C) 1998 Elsevier Science B.V. All rights reserved.