Advancing paternal age and bipolar disorder
Advancing paternal age and bipolar disorder
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DOI：
10.1001/archpsyc.65.9.1034
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发表时间：
2008-09-01
影响因子：
--
通讯作者：
Hultman, Christina M.
中科院分区：
文献类型：
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作者：
Frans, Emma M.;Sandin, Sven;Hultman, Christina M.
内容：据报道，父亲的年龄提前作为一个危险因素neurodevelopmental disorders.Objectives：要确定是否先进的父亲年龄与BPD的后代的风险增加，并评估是否有任何差异的风险时，分析早发性BPD separately.Design：一个全国性的巢式病例对照研究的基础上，瑞典登记进行。使用条件logistic回归分析来估计年长父亲的后代患BPD的风险，控制了产次、母亲年龄、社会经济地位和父母精神病家族史的潜在混杂因素。设置：通过连接全国多代登记和医院出院登记来识别7 328 1.00个个体及其生物学父母。参与者：共确定了1.3428例在至少2次单独入院时诊断为BPD的患者。五个健康对照组匹配的性别和出生年份被随机分配到each.Main Outcome Measure：双相情感障碍的基础上ICD代码在出院treatment.Results：父亲的年龄和风险之间的关联BPD在后代的老年男性被注意到。风险随着父亲年龄的增长而增加。在控制了产次、母亲年龄、社会经济地位和精神病家族史后，55岁及以上男性的后代被诊断为BPD的可能性是20至24岁男性后代的1.37倍（95%置信区间101，1.02-1.84）。母亲的年龄效应不太明显。对于早发性（< 20岁）的情况下，父亲的年龄的影响要强得多（优势比，2.63 95%CI 1.19-5.81），而没有统计学意义的母亲年龄的影响被发现。结论：先进的父亲年龄是一个危险因素，BPD的后代。研究结果与父亲年龄增加神经发育障碍易感基因新生突变风险的假设一致。
Context: Advancing paternal age has been reported as a risk factor for neurodevelopmental disorders.Objectives: To determine whether advanced paternal age is associated with an increased risk of BPD in the offspring and to assess if there was any difference in risk when analyzing patients with early-onset BPD separately.Design: A nationwide nested case-control study based on Swedish registers was performed. Risk for BPD in the offspring of older fathers was estimated using conditional logistic regression analysis controlling for potential confounding of parity, maternal age, socioeconomic status, and parental family history of psychotic disorders.Setting: Identification of 7 328 1.00 individuals and their biological parents by linking the nationwide Multigeneration Register and the Hospital Discharge Register.Participants: A total of 1.3 428 patients with a BPD diagnosis on at least 2 separate hospital admissions was identified. Five healthy control subjects matched for sex and year of birth were randomized to each.Main Outcome Measure: Bipolar disorder based on ICD codes at discharge from hospital treatment.Results: An association between paternal age and risk for BPD in the offspring of older men was noted. The risk increased with advancing paternal age. After controlling for parity, maternal age, socioeconomic status, and family history of psychotic disorders, the offspring of men 55 years and older were 1.37 (95% confidence interval 101, 1.02-1.84) times more likely to be diagnosed as having BPD than the offspring of men aged 20 to 24 years. The maternal age effect was less pronounced. For early-onset (< 20 years) cases, the effect of paternal age was much stronger (odds ratio, 2.63 95% CI 1.19-5.81), whereas no statistically significant maternal age effect was found.Conclusions: Advanced paternal age is a risk factor for BPD in the offspring. The results are consistent with the hypothesis that advancing paternal age increases the risk for de novo mutations in susceptibility genes for neurodevelopmental disorders.