Magnetic resonance imaging of diffuse axonal injury: Quantitative assessment of white matter lesion volume
Magnetic resonance imaging of diffuse axonal injury: Quantitative assessment of white matter lesion volume
复制标题
DOI：
10.1089/neu.2006.0214
复制
发表时间：
2007-04-01
影响因子：
4.2
通讯作者：
Devous, Michael, Sr.
中科院分区：
文献类型：
--
作者：
de la Plata, Carlos Marquez;Ardelean, Andreea;Devous, Michael, Sr.
Diffuse axonal injury (DAI) is a common mechanism of traumatic brain injury (TBI) for which there is no well-accepted anatomic measures of injury severity. The present study aims to quantitatively assess DAI by measuring white matter lesion volume visible in fluid-attenuated inversion recovery (FLAIR) weighted images and to determine whether higher lesion volumes are associated with unfavorable functional outcome 6 months after injury. Twenty-four patients who experienced moderate to severe TBI without extra-axial or major cortical contusions were included in this study. Lesion volume was assessed by quantifying areas of hyperintensities in the white matter utilizing digitized FLAIR images. Two independent raters processed the magnetic resonance (MR) images and determined the total DAI volume. Functional outcome was assessed at 6 months after injury using the Glasgow Outcome Scale-Extended (GOSE). Interclass correlation analyses showed very high interrater reliability for each measure between the two raters (Interclass Correlation Coefficient = 0.95,p
