Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats.
Radix Angelica Sinensis Promotes Synaptic Plasticity During Cognitive Recovery in Chronically Stressed Rats.
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DOI：
10.2174/1567202612666150603125710
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发表时间：
2015-07
影响因子：
2.1
通讯作者：
Min Deng;Huimin Sun;Jun Shen;Yuan-teng Fan;Lei Zhang;Junjian Zhang
中科院分区：
文献类型：
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作者：
Min Deng;Huimin Sun;Jun Shen;Yuan-teng Fan;Lei Zhang;Junjian Zhang
慢性压力的积累与认知功能障碍有关。当归具有治疗阿尔茨海默病和血管性痴呆的神经保护作用。然而，RAS对慢性应激引起的认知障碍的影响尚未得到研究。在本研究中，RAS显著缓解了慢性约束应激大鼠的认知缺陷。这种神经保护作用与通过改善场兴奋性突触后电位振幅、减轻海马突触和神经元结构的不利改变、增加海马脑源性神经营养因子、微管相关蛋白-2和突触素的水平来增强突触效能有关。这些发现为RAS治疗慢性应激引起的神经元退化提供了初步证据。
The accumulation of chronic stress is associated with cognitive dysfunction. Radix Angelica Sinensis (RAS) has been shown to have neuroprotective potential for treating Alzheimer's disease and vascular dementia. However, the impact of RAS on cognitive impairment induced by chronic stress has not been studied. In the present study, RAS significantly alleviated cognitive deficits in rats subjected to chronic restraint stress. This neuroprotective effect was associated with enhancement of synaptic efficacy by improving field excitatory postsynaptic potential amplitudes, alleviating adverse alterations in the structure of synapses and neurons in the hippocampus, and increasing the levels of brain-derived neurotrophic factor, microtubule-associated protein-2, and synaptophysin in the hippocampus. These findings provide initial evidence for the therapeutic potential of RAS for the treatment of neuronal deterioration caused by chronic stress.