Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
复制标题
抗 IL-33 抗体治疗可抑制过敏性哮喘小鼠模型的气道炎症
DOI：
10.1016/j.bbrc.2009.06.008
复制
发表时间：
2009-08-14
影响因子：
3.1
通讯作者：
Huang, Tian
中科院分区：
文献类型：
--
作者：
Liu, Xiaojin;Li, Mingcai;Huang, Tian
白细胞介素 (IL)-33 是最近描述的 IL-1 家族成员，已被证明可诱导 2 型 T 辅助细胞因子的产生。在这项研究中，评估了抗 IL-33 抗体对卵清蛋白致敏和攻击小鼠肺部炎症的抵抗力。在致敏和抗原攻击之前，腹膜内给予抗IL-33或对照抗体(150μg/小鼠)五剂。与施用对照抗体相比，用抗IL-33治疗显着降低血清IgE分泌、嗜酸性粒细胞和淋巴细胞的数量以及支气管肺泡灌洗液中IL-4、IL-5和IL-13的浓度。肺组织的组织学检查表明，抗IL-33显着抑制过敏原诱导的肺部嗜酸性粒细胞炎症和粘液分泌过多。我们的数据首次证明抗IL-33抗体可以预防小鼠模型中哮喘的发展，并表明阻断IL-33可能是过敏性哮喘的新治疗策略。 (C) 2009 Elsevier Inc. 保留所有权利。
Interleukin (IL)-33 is a recently described member of the IL-1 family and has been shown to induce production of T helper type 2 cytokines. In this study, an anti-IL-33 antibody was evaluated against pulmonary inflammation in mice sensitized and challenged with ovalbumin. The anti-IL-33 or a control antibody (150 mu g/mouse) was given intraperitoneally as five doses before the sensitization and antigen challenge. Treatment with anti-IL-33 significantly reduced serum IgE secretion, the numbers of eosinophils and lymphocytes, and concentrations of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid compared with administration of a control antibody. Histological examination of lung tissue demonstrated that anti-IL-33 significantly inhibited allergen-induced lung eosinophilic inflammation and mucus hypersecretion. Our data demonstrate for the first time that anti-IL-33 antibody can prevent the development of asthma in a mouse model and indicate that blockade of IL-33 may be a new therapeutic strategy for allergic asthma. (C) 2009 Elsevier Inc. All rights reserved.