Effect of Paternal Alcohol and Drug Dependence on Offspring Conduct Disorder: Gene-Environment Interplay
Effect of Paternal Alcohol and Drug Dependence on Offspring Conduct Disorder: Gene-Environment Interplay
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DOI：
10.15288/jsad.2010.71.652
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发表时间：
2010-09-01
影响因子：
3.4
通讯作者：
Heath, Andrew
中科院分区：
文献类型：
--
作者：
Haber, Jon Randolph;Bucholz, Kathleen K.;Heath, Andrew
目的：物质使用障碍和外化障碍不仅经常共病，而且经常在几代人的家庭中共同发生。本研究采用双胞胎后代设计，探讨了遗传和环境影响在父系药物依赖或酒精依赖史与后代行为障碍之间关系中的作用。方法：参与者是来自越南时代双胞胎登记处的男性双胞胎（n = 1，774），他们的后代（n = 1，917）和后代的母亲（n = 1，202）。双胞胎有药物依赖史，酒精依赖史，或两者都没有。根据父亲和他的双胞胎兄弟的药物依赖或酒精依赖史和接合性，构建风险组，以反映不同水平的遗传和环境风险，然后用于预测后代的行为障碍。结果如下：在控制了潜在的混杂变量后，有药物依赖或酒精依赖史的男性的后代与没有这种历史的男性的后代相比，行为障碍的发生率显着更高。遗传风险较高的后代有较高的行为障碍率。环境风险较低的高风险后代行为障碍的发生率较低，但仅限于父亲有药物依赖风险的情况。当父亲有酒精依赖史时，较低的环境风险并不影响后代行为障碍的发生率。结论：与父亲药物依赖和父亲酒精依赖史相关的遗传风险预测后代行为障碍风险，但只有与父亲药物依赖史相关的风险通过低风险环境得到缓解。这些结果表明，一个显着的基因环境互作效应。（J Stud.酒精药物，71，652-663，2010）
Objective: Not only are substance-use disorders and externalizing disorders frequently comorbid, they often co-occur in families across generations. The current study examined the role of genetic and environmental influences in the relationship between paternal histories of drug dependence or alcohol dependence and offspring conduct disorder using an offspring-of-twins design. Method: Participants were male twins (n = 1,774) from the Vietnam Era Twin Registry, their offspring (n = 1,917), and mothers of the offspring (n = 1,202). Twins had a history of drug dependence, alcohol dependence, or neither. Based on the father's and his co-twin's drug-dependence or alcohol-dependence history and zygosity, risk groups were constructed to reflect different levels of genetic and environmental risk that were then used to predict offspring conduct disorder. Results: After controlling for potentially confounding variables, the offspring of men with a history of drug dependence or alcohol dependence had significantly higher rates of conduct disorder, compared with offspring of men without this history. Offspring at higher genetic risk had higher rates of conduct disorder. High-risk offspring at lower environmental risk had lower rates of conduct disorder but only in the case of paternal drug-dependence risk. Lower environmental risk did not influence rates of offspring conduct disorder when the father had an alcohol-dependence history. Conclusions: Genetic risk associated with both paternal drug-dependence and paternal alcohol-dependence histories predicted offspring conduct-disorder risk, but only risk associated with paternal drug-dependence history was mitigated by having a low-risk environment. These results demonstrated a significant gene environment interaction effect. (J Stud. Alcohol Drugs, 71, 652-663, 2010)