Antibacterial evaluation of cnicin and some natural and semisynthetic analogues
Antibacterial evaluation of cnicin and some natural and semisynthetic analogues
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DOI：
10.1055/s-2003-38491
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发表时间：
2003-03-01
期刊：
影响因子：
2.7
通讯作者：
Senatore, F
中科院分区：
文献类型：
--
作者：
Bruno, M;Rosselli, S;Senatore, F
以大麦果内酯倍半萜类物质——山药素为原料，制备了一些茄油内酯衍生物。对化合物的抗菌活性进行了测试。8,15-二酯表现出良好的活性，与牛油素相当。15-单酯化合物活性不高，表明C-8位的酯化反应是具有抗菌性能的重要结构特征。
Some ester derivatives of salonitenolide have been prepared from cnicin, a germacranolide sesquiterpenoid. The compounds were tested for their antibacterial activity. The 8,15-diesters showed a good activity, comparable with that of cnicin. The 15-monoester compounds were not very active showing that esterification at the C-8 position is an important structural feature for antibacterial properties.