Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
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DOI：
10.3390/ijms141224706
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发表时间：
2013-12-18
影响因子：
5.6
通讯作者：
Fruci D
中科院分区：
文献类型：
--
作者：
Alisi A;Cho WC;Locatelli F;Fruci D
化疗是治疗癌症的主要方式之一。然而，其有效性受到多药耐药（MDR）的限制。多种机制可以解释化疗后肿瘤MDR基因/蛋白的上调。已知癌症干细胞（CSC）发挥主调节器的作用。因此，了解调控CSCs某些性状的机制可能有助于设计有效的策略来克服化疗耐药性。不同的CSC表型已被确定，包括在一些儿科恶性肿瘤中发现的那些。由于儿童实体瘤与成人实体瘤有显著差异，本文旨在概述常见实体瘤中MDR与CSC之间的机制关系，特别是关注神经母细胞瘤和肝母细胞瘤中CSC与MDR之间关系的临床和实验证据。最后，一些新的方法，如同时靶向多个关键转录因子管理干细胞，以及基于纳米颗粒的方法也将简要讨论。
Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help design efficient strategies to overcome chemoresistance. Different CSC phenotypes have been identified, including those found in some pediatric malignancies. As solid tumors in children significantly differ from those observed in adults, this review aims at providing an overview of the mechanistic relationship between MDR and CSCs in common solid tumors, and, in particular, focuses on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing the stemness of CSCs, as well as nanoparticle-based approaches will also be briefly addressed.
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