Association of Osteoglycin and FAM5C with Bone Turnover Markers, Bone Mineral Density, and Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus
Association of Osteoglycin and FAM5C with Bone Turnover Markers, Bone Mineral Density, and Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus
复制标题
骨甘氨酸和 FAM5C 与患有 2 型糖尿病的绝经后女性骨转换标志物、骨矿物质密度和椎骨骨折的关系
DOI：
10.1016/j.bone.2016.11.007
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发表时间：
2017
期刊：
影响因子：
4.1
通讯作者：
Sugimoto T
中科院分区：
文献类型：
--
作者：
Tanaka KI;Kanazawa I;Kaji H;Sugimoto T
目的越来越多的证据表明肌肉和骨骼之间存在相互关系。先前的体外研究表明，肌肉源性因子骨甘氨酸（OGN）和具有序列相似性的家族5，成员C（FAM5C）调节成骨细胞分化。然而，目前还没有研究循环 OGN 和 FAM5C 与人类骨代谢之间关系的报道。设计我们进行了一项横断面研究，调查了 156 名患有 2 型糖尿病的绝经后女性的血清 OGN 和 FAM5C 水平以及通过全身双能 X 射线骨密度测定法检查的肌肉质量与骨矿物质密度 (BMD)、骨转换标志物以及椎体骨折 (VF) 的存在之间的关系(T2DM)。结果根据年龄、T2DM 病程、体重指数、血清肌酐和 log(糖化血红蛋白) 进行调整的多元回归分析显示，log(OGN) 与股骨颈 BMD 呈负相关 (β=−0.17,p=0.014)。患有 VF 的受试者的血清 OGN 水平高于无 VF 的受试者 [平均值 ± 标准差 (SD)：100.2 ± 84.7 与 74.4 ± 31.7 pg/mL，p= 0.013]。此外，针对上述混杂因素进行调整的逻辑回归分析表明，血清 OGN 水平与 VF 的存在呈正相关（比值比 = 1.84，95% 置信区间 = 每 SD 增加 1.03–3.29，p = 0.039）。相比之下，血清 FAM5C 水平和肌肉质量指数均与骨转换标志物和 VF 的存在无关。结论本研究首次表明，血清 OGN 水平较高与绝经后 T2DM 女性 BMD 降低和椎骨骨折风险增加相关。
ObjectiveAccumulating evidence suggests a reciprocal relationship between muscle and bone. Previous in vitro studies showed that the muscle-derived factors, osteoglycin (OGN) and family with sequence similarity 5, member C (FAM5C), regulate osteoblastic differentiation. However, there are no reports investigating the association between circulating OGN and FAM5C and bone metabolism in humans.DesignWe conducted a cross-sectional study and investigated the association of serum OGN and FAM5C levels and muscle mass examined by whole-body dual-energy x-ray absorptiometry with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus (T2DM).ResultsMultiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and log(hemoglobin A1c) showed that log(OGN) was negatively associated with BMD at the femoral neck (β = − 0.17,p= 0.014). Serum OGN levels were higher in subjects with VFs than in those without VFs [mean ± standard deviation (SD): 100.2 ± 84.7 vs. 74.4 ± 31.7 pg/mL,p= 0.013]. Moreover, logistic regression analysis adjusted for the confounding factors described above showed that the serum OGN level was positively associated with the presence of VFs (odds ratio = 1.84, 95% confidence interval = 1.03–3.29 per SD increase,p= 0.039). In contrast, neither the serum FAM5C level nor muscle mass indices were associated with bone turnover markers and the presence of VFs.ConclusionsThe present study showed for the first time that higher serum OGN levels were associated with decreased BMD and increased risk of vertebral fractures in postmenopausal women with T2DM.