Effects of ovariectomy in beagle dogs.
Effects of ovariectomy in beagle dogs.
复制标题
比格犬卵巢切除术的影响。
DOI：
10.1016/8756-3282(87)90128-1
复制
发表时间：
1987
期刊：
影响因子：
4.1
通讯作者：
Dannucci,G
中科院分区：
文献类型：
--
作者：
Martin,RB;Butcher,RL;Sherwood,LL;Buckendahl,P;Boyd,RD;Farris,D;Sharkey,N;Dannucci,G
选取3 ~ 7岁的Beagle犬，分别切除卵巢（n= 9）或假手术（n= 6），随访48周，测定体重、胫骨骨矿物质含量（BMC）和血清生化指标。杀死后，测量骨强度和组织形态。卵巢切除术（OX）显著降低血清雌二醇和雌二醇浓度及其逐月变化。术后前12周，OX犬的皮质BMC有短暂性下降，48周后各组间无差异。血清骨钙素升高，但对血清碱性磷酸酶、钙、磷或降钙素的影响不大。OX增加了皮质骨中四环素标记骨的数量，但减少了四环素标记的小梁表面的百分比。OX对骨骼组成和皮质面积的损失没有显著影响，但统计上有15%的脊柱骨小梁骨丢失。然而，骨强度在献祭时并没有明显的影响。
Beagle dogs 3–7 years old were ovariectomized (n= 9) or sham operated (n= 6) and followed for 48 weeks with measurements of body weight, tibial shaft bone mineral content (BMC), and serum biochemistry. Following killing, measurements were made of bone strength and histomorphometry. Ovariectomy (OX) significantly reduced serum estrone and estradiol concentrations and their variability from month to month. There was a transient decrease in cortical BMC of the OX dogs during the first 12 postoperative weeks but no difference between the groups after 48 weeks. Serum osteocalcin was elevated, but there was little effect on serum alkaline phosphatase, Ca, P, or calcitonin. OX increased the number of tetracycline-labeled osteons in cortical bone but reduced the percent trabecular surface labeled with tetracycline. OX produced no significant changes in the composition of the bones or loss of cortical area, but a statistically significant 15% trabecular bone loss occurred in the spine. However, bone strength had not been significantly affected at the time of sacrifice.