Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients.
Advanced glycation end products (AGEs) in relation to atherosclerotic lipid profiles in middle-aged and elderly diabetic patients.
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DOI：
10.1186/1476-511x-10-228
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发表时间：
2011-12-06
影响因子：
4.5
通讯作者：
Hung YR
中科院分区：
文献类型：
--
作者：
Chang JB;Chu NF;Syu JT;Hsieh AT;Hung YR
目的：评估台湾地区老年糖尿病患者的年龄与动脉粥样硬化性血脂的关系。在年龄和性别匹配后，我们选择了207名糖尿病患者和174名糖尿病蛋白尿患者。用标准方法测定血脂谱，包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDLC)。用免疫测定法测定AGEs。总体而言，男性的体重较高；然而，女性的年龄、空腹血糖(GLU)、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平高于男性，总胆固醇/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇和甘油三酯/高密度脂蛋白胆固醇的比率也高于男性。与血糖或血红蛋白A1c相比，AGEs与TG水平、TCL/LDL-C、LDL-C/HDL-C和TG/HDL-C比值的相关性更强。受试者有更高的年龄水平(≧2.0AU)和更多的不良血脂谱。AGEs似乎是一个很好的生物标记物，可以用来评估糖尿病和老年糖尿病患者的动脉粥样硬化疾病之间的联系。
To evaluate the association between AGEs and atherosclerotic lipid profiles among aging diabetic patients in Taiwan. After age and gender matching, we selected 207 diabetic subjects and 174 diabetic subjects with proteinuria. Lipid profiles, including total cholesterol (TC), triglycerides (TG), high density cholesterol-lipoprotein (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured using standard methods. AGEs were measured with the immunoassay method. In general, males were heavier; however, females had higher AGEs, fasting glucose (GLU), TC, HDL-C and LDL-C levels than males, and had higher TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C ratios compared to males. AGEs were more strongly correlated with TG levels and TCL/LDL-C, LDL-C/HDL-C and TG/HDL-C ratios when compared to glucose or hemoglobin A1c. Subjects had higher AGEs levels (≧ 2.0 AU) with more adverse lipid profiles. AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes.