Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo
Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo
复制标题
DOI：
10.1016/j.gep.2010.08.004
复制
发表时间：
2010-10-01
影响因子：
1.2
通讯作者：
Fisher, Paul B.
中科院分区：
文献类型：
--
作者：
Jeon, Hyun Yong;Choi, Murim;Fisher, Paul B.
星形胶质细胞升高基因-1（AEG-1）的表达在多种人类癌症中升高，包括脑肿瘤、成神经细胞瘤、黑素瘤、乳腺癌、非小细胞肺癌、肝癌、前列腺癌和食道癌。该基因在肿瘤细胞生长、侵袭、血管生成和转移进展中起关键作用。此外，AEG-1的过表达通过激活PI 3 K-Akt信号通路保护原代和转化细胞免受凋亡诱导信号的影响。这些结果表明AEG-1与肿瘤发生密切相关，并可能成为多种人类癌症的潜在治疗靶点。然而，AEG-1的正常生理功能需要澄清。我们目前分析了AEG-1在小鼠发育过程中的表达模式。AEG-1在E8.5至E9.5的早期发育期中表达于中脑至后脑、额鼻突、四肢和咽弓。此外，在E12.5-E18.5阶段，AEG-1定位于脑、嗅觉和骨骼系统，表明在神经发生中的作用，以及皮肤（包括毛囊）和肝脏中，这是AEG-1与肿瘤发展和进展有关的器官部位。AEG-1与Ki-67共定位，表明在细胞增殖中的作用，如先前在肿瘤发生中所揭示的。两者合计，这些结果表明，AEG-1可能发挥突出的作用，在正常小鼠发育过程中的细胞增殖以及分化的背景下，AEG-1的表达的时间调节可能需要在特定的阶段和特定的组织在发展过程中。(C)2010爱思唯尔B.V保留所有权利。
Expression of astrocyte elevated gene-1 (AEG-1) is elevated in multiple human cancers including brain tumors, neuroblastomas, melanomas, breast cancers, non-small cell lung cancers, liver cancers, prostate cancers, and esophageal cancers. This gene plays crucial roles in tumor cell growth, invasion, angiogenesis and progression to metastasis. In addition, over-expression of AEG-1 protects primary and transformed cells from apoptosis-inducing signals by activating PI3K-Akt signaling pathways. These results suggest that AEG-1 is intimately involved in tumorigenesis and may serve as a potential therapeutic target for various human cancers. However, the normal physiological functions of AEG-1 require clarification. We presently analyzed the expression pattern of AEG-1 during mouse development. AEG-1 was expressed in mid-to-hindbrain, fronto-nasal processes, limbs, and pharyngeal arches in the early developmental period from E8.5 to E9.5. In addition, at stages of E12.5-E18.5 AEG-1 was localized in the brain, and olfactory and skeletal systems suggesting a role in neurogenesis, as well as in skin, including hair follicles, and in the liver, which are organ sites in which AEG-1 has been implicated in tumor development and progression. AEG-1 co-localized with Ki-67, indicating a role in cell proliferation, as previously revealed in tumorigenesis. Taken together, these results suggest that AEG-1 may play a prominent role during normal mouse development in the context of cell proliferation as well as differentiation, and that temporal regulation of AEG-1 expression may be required during specific stages and in specific tissues during development. (C) 2010 Elsevier B.V All rights reserved.