Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone
Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone
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DOI：
10.1016/j.ijrobp.2004.11.002
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发表时间：
2005-07-01
影响因子：
7
通讯作者：
Huang, EY
中科院分区：
文献类型：
--
作者：
Yeh, SA;Tang, Y;Huang, EY
目的：本研究的目的是描述的治疗结果和治疗相关的并发症的鼻咽癌（NPC）患者接受放射治疗的单独。方法和材料：回顾性分析849例连续NPC患者治疗1983年和1998年在我们的机构。分析了潜在显著的患者相关和治疗相关变量。结果：这些患者的5年总生存率和无瘤生存率分别为59%和52%。晚期咽旁间隙（PPS）侵犯的预后价值高于PPS侵犯。多个颈部淋巴结（LN）的参与被证明是一个最强大的独立预后因素中的所有LN相关参数。外部束辐射剂量超过72戈伊与听力障碍，牙关紧闭，颞叶necrosis.Conclusions的发病率显着较高：我们建议PPS的程度应予以澄清和分层。在美国癌症联合委员会的进一步修订中，多个颈部淋巴结受累可纳入N分类。不建议对淋巴结阴性颈部进行增强照射。对于淋巴结阳性的颈部，需要加强照射，初始和加强照射之间的较长间隔将降低颈部纤维化的发生率，而不会影响颈部控制率。(c)2005年爱思唯尔公司
Purpose: The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone.Methods and Materials: Retrospective analysis was performed on 849 consecutive NPC patients treated between 1983 and 1998 in our institution. Potentially significant patient-related and treatment-related variables were analyzed. Radiation-related complications were recorded.Results: The 5-year overall and disease-free survival rates of these patients were 59% and 52%, respectively. Advanced parapharyngeal space (PPS) invasion showed stronger prognostic value than PPS invasion. Multiple neck lymph node (LN) involvement was demonstrated to be one of the most powerful independent prognostic factors among all LN-related parameters. External beam radiation dose more than 72 Gy was associated with significantly higher incidence of hearing impairment, trismus, and temporal lobe necrosis.Conclusions: We recommend that the extent of PPS should be clarified and stratified. Multiple neck LN involvement could be integrated into the N-classification in further revisions of the American Joint Committee on Cancer stage. Boost irradiation is not suggested for node-negative necks. For node-positive necks, boost irradiation is indicated and a longer interval between initial and boost irradiation would reduce the incidence of neck fibrosis without compromising the neck control rate. (c) 2005 Elsevier Inc.