Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms.
Patterns of partnership: surveillance and mimicry in host-microbiota mutualisms.
复制标题
伙伴关系模式：宿主微生物群互利共生中的监视和模仿。
DOI：
10.1016/j.mib.2020.01.012
复制
发表时间：
2020
影响因子：
5.4
通讯作者：
Guillemin,Karen
中科院分区：
文献类型：
--
作者：
Wiles,TravisJ;Guillemin,Karen
突出显示宿主监测其常驻微生物相关竞争活动（MACA）。MACA针对原核和真核细胞共同的细胞脆弱性。宿主部署MACA模拟物来控制常驻微生物和入侵病原体。MACA的宿主感知调节防御，修复，宿主对MACA的感知模拟了组织防御和发育的程序。动物和植物组织监测的微生物线索库不仅包括分子，还包括微生物活动。这些包括损伤膜、降解细胞物质和清除资源的典型病原体策略。然而，这些活动并不限于病原体。相反，它们描述了生活在多物种群落中的微生物的竞争策略，就像那些通常发现的殖民宿主组织一样。宿主组织也会进行类似的活动，以控制微生物。我们认为，宿主的监视和模仿微生物相关的竞争活动（MACAs），来自生活在混合微生物群落的进化历史，塑造了当代动物和植物组织的防御，修复，代谢和发展计划。
HighlightsHosts monitor their resident Microbial-Associated Competitive Activities (MACAs).MACAs target cellular vulnerabilities common to prokaryotic and eukaryotic cells.Hosts deploy MACA mimics to control resident microbes and invading pathogens.Host sensing of MACAs regulates tissue programs of defense, repair, and growth.Host sensing of MACA mimics refines programs of tissue defense and development.The repertoire of microbial cues monitored by animal and plant tissues encompasses not just molecules but also microbial activities. These include typical pathogen strategies of injuring membranes, degrading cellular material, and scavenging resources. These activities, however, are not exclusive to pathogens. Instead, they characterize the competitive strategies of microbes living in multispecies communities, like those typically found colonizing host tissues. Similar activities are also deployed by host tissues to keep microbes in check. We propose that host surveillance and mimicry of Microbial-Associated Competitive Activities (MACAs), derived from an evolutionary history of living in mixed microbial communities, has shaped contemporary animal and plant tissue programs of defense, repair, metabolism, and development.