Evaluation of flunixin meglumine as an adjunct treatment for diarrhea in dairy calves
Evaluation of flunixin meglumine as an adjunct treatment for diarrhea in dairy calves
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DOI：
10.2460/javma.2003.223.1329
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发表时间：
2003-11-01
期刊：
影响因子：
--
通讯作者：
Reynolds, JP
中科院分区：
文献类型：
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作者：
Barnett, SC;Sischo, WM;Reynolds, JP
目的：评价氟尼辛葡甲胺辅助治疗小牛腹泻的疗效。设计-临床试验。动物-115头1-21天大的患腹泻的牛犊被随机分配给不服用氟尼辛葡甲胺(对照组)、单剂量的氟尼辛葡甲胺(2.2 mg/kg[1.0 mg/lb])，或间隔24小时注射2剂氟尼辛葡甲胺。在登记参加试验之前，测量了血清免疫球蛋白浓度和PCV。每天对小牛进行评估，以确定直肠温度、粪便稠度、行为举止和皮肤弹性评分。主要的分析结果是患病天数(患病天数)。结果：与对照组相比，服用单剂量氟尼辛葡甲胺的粪血牛犊的患病天数和抗菌治疗更少。虽然不显著，但在24小时内给予2剂氟尼辛葡甲胺的小牛比未治疗的对照小牛的患病天数更少。无论腹泻的严重程度如何，没有粪血的牛犊都不会从使用氟尼辛中受益。对于有粪血的犊牛，被动输注失败(低血清免疫球蛋白浓度)是增加患病天数的独立危险因素。结论和临床相关性-单剂量氟尼辛葡甲胺治疗导致有粪血的犊牛的抗菌治疗和患病天数减少。正如在其他研究中观察到的，被动移植失败的小牛有较高的不良结局风险。这强调了在奶牛场开发和实施有效的初乳输送计划的重要性。
Objective-To assess the use of flunixin meglumine as an adjunct treatment for diarrhea in calves.Design-Clinical trial. Animals-115 calves with diarrhea that were 1 to 21 days old at enrollment.Procedure-Calves that developed diarrhea were randomly assigned to receive no flunixin meglumine (controls), a single dose of flunixin meglumine (2.2 mg/kg [1.0 mg/lb]), or 2 doses of flunixin meglumine administered 24 hours apart. Serum IgG concentration and PCV were measured prior to enrollment in the trial. Calves were evaluated daily to determine rectal temperature, fecal consistency, demeanor, and skin elasticity score. The primary analytic outcome was days of sickness (morbid-days).Results-Calves with fecal blood and treated with a single dose of flunixin meglumine had fewer morbid-days and antimicrobial treatments, compared with controls. Although not significant, calves given 2 doses of flunixin meglumine in 24 hours had fewer morbid-days than untreated control calves. Regardless of severity of diarrhea, calves without fecal blood did not benefit from the use of flunixin. For calves with fecal blood, failure of passive transfer (low serum IgG concentration) was an independent risk factor for increased morbid-days.Conclusions and Clinical Relevance-Treatment with a single dose of flunixin meglumine resulted in fewer antimicrobial treatments and morbid-days in calves with fecal blood. As observed in other studies, calves with failure of passive transfer were at high risk for poor outcomes. This emphasizes the importance of developing and implementing effective colostrum delivery programs on dairy farms.