Volatile Organic Compound Analysis by an Inertial Spray Extraction Interface Coupled to an Ion Trap Mass Spectrometer
Volatile Organic Compound Analysis by an Inertial Spray Extraction Interface Coupled to an Ion Trap Mass Spectrometer
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通过与离子阱质谱仪联用的惯性喷雾萃取接口进行挥发性有机化合物分析
DOI：
10.1021/ac00120a017
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发表时间：
1995
影响因子：
7.4
通讯作者：
J. Montgomery
中科院分区：
文献类型：
--
作者：
F. St;O. Mamer;J. Brunet;B. Vachon;R. Tardif;T. Abribat;C. Rosiers;J. Montgomery
开发了一种新的界面，用于直接分析水溶液中的挥发性有机化合物（VOCs），而无需事先进行样品处理。该装置由一个喷嘴组成，该喷嘴在喷雾室中垂直向下，该喷雾室又通过氦射流分离器耦合到离子阱质谱仪。在氦气载气和快速进样的帮助下，喷嘴将液体还原为气溶胶。气溶胶的大表面积允许VOC在气相和液相之间快速平衡。气溶胶液滴通过它们的惯性撞击在喷雾室的底板上，在那里它们聚结以随后从界面去除。挥发性有机化合物从界面携带的氦气逆流喷雾。合并的VOC-氦气混合物通过喷射分离器，该分离器去除大部分载气，然后通过离子阱质谱仪分析浓缩的VOC。这种惯性喷雾萃取质谱法非常灵敏，并且对于所分析的大多数化合物（例如，检测到苯为90 ppt）。利用该系统，我们分析了氟烷血液从麻醉猪。良好的相关性，获得此接口和传统的顶空气相色谱分析的甲苯和二甲苯在血液中暴露于这些化合物的大鼠和加标人血之间。
A new interface has been developed for direct analysis of volatile organic compounds (VOCs) from aqueous solutions without prior sample treatment. The device consists of a nozzle directed vertically downward in a spray chamber, which is in turn coupled through a helium jet separator to an ion trap mass spectrometer. The nozzle reduces the liquid to an aerosol with the help of a helium carrier gas and rapid sample injection. The large surface area of the aerosol permits a rapid equilibration of the VOCs between the gas and liquid phases. The aerosol droplets impinge by their inertia on the floor of the spray chamber, where they coalesce for subsequent removal from the interface. The VOCs are carried from the interface by the helium flowing countercurrent to the spray. The combined VOC-helium mixture passes through a jet separator, which removes most of the carrier gas, and the concentrated VOCs are then analyzed by an ion trap mass spectrometer. This inertial spray extraction mass spectrometry method is very sensitive and has detection limits of <1 ppb for most compounds analyzed (e.g., benzene is detected at 90 ppt). Using this system, we have analyzed halothane in blood from an anesthetized pig. Excellent correlations are obtained between this interface and conventional headspace gas chromatography for the analysis of toluene and xylene in blood from rats exposed to these compounds and for spiked human blood.